Correlation between depressive symptoms and cardiovascular-metabolic comorbidities trajectories in middle-aged and elderly of China
Objective To understand the correlation between depressive symptoms and cardiovascular-metabolic comorbidities(CMM)trajectories in Chinese residents(≥45 years old),and provide the basis for prevention and control and health management of CMM in middle-aged and elderly people.Methods Based on data from"the China Health and Retirement Longitudinal Study(CHARLS)in 2015 and 2018",11 182 middle-aged and older adults without CMM in 2015 served as the subjects.The investigation included the basic information,prevalence of chronic diseases and depression symptom measure.The information of CMM trajectories was from the data in 2018.The t test,Kruskal-Wallis H test,x2 test and multi-nominal logit regression model were used to analyze the data.The used software was Stata 16.0.Results From 2015 to 2018,cardiometabolic disease(CMD)condition in 7 736 cases of 11 182 subjects(69.18％)did not change,1 686 cases without CMD(15.08％)developed to one type of CMD,645 cases without CMD(5.77％)developed to CMM,and 1 115 cases with one type CMD(9.97％)developed to CMM.The multi-nominal logit regression model analysis showed that as compared with subjects without depressive symptoms,the risk of developing from no CMD to one type of CMD(OR=1.21,95％CI:1.08-1.36),from no CMD to CMM(OR=1.68,95％CI:1.41-2.01),from one type of CMD to CMM(OR=1.74,95％CI:1.51-2.00)in subjects with depressive symptoms increased.The risk of CMM trajectory changes was higher in middle-aged and elderly people with depressive symptoms in all age and gender groups,as well as those living in rural areas,with low education level and non-cohabitation(P＜0.05).As compared with the subjects with no depression symptoms,the risk of CMM trajectory changes in the subjects living alone with depression symptoms(OR=2.47,95％CI:1.70-3.60)were much higher than those in the subjects not living alone with depression symptoms(OR=1.64,95％CI:1.41-1.90),Pinteraction＜0.05.Conclusion The risk of CMM trajectory changes in middle-aged and elderly people with depressive symptoms is much higher.It should pay attention to the mental health of middle-aged and elderly people,and should formulate the related intervention measures to reduce the disease burden of cardiovascular-metabolic comorbidities.
Middle-aged and elderly peopleDepressive symptomsCardiovascular-metabolic comorbidities
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