Interaction of dyslipidemia and elevated alanine aminotransferase on hyperuricemia
Objective To explore the interaction between dyslipidemia and elevated alanine aminotransferase(ALT)on hyperuricemia(HUA),and provide the scientific basis for the prevention and treatment of HUA.Methods From May 2020 to June 2021,the multi-stage stratified random sampling method was used to select 4 725 residents(45-95 years old)from Anning city as the subjects.The investigation was performed with the questionnaire,physical examination and laboratory test.The t test,rank sum test,x2 test and uni-variate and multivariate logistic regression analysis were used to analyze the data.Multivariate logistic regression multiplication model and addition model were used to analyze the interaction of dyslipidemia and elevated alanine aminotransferase on hyperuricemia disease.The used software was SAS 9.4.Results Among 4 725 subjects,there were 1 681 cases with HUA(35.58％),1 667 cases with dyslipidemia(35.28％),and 397 cases with elevated ALT levels(8.40％).The co-occurrence rate of dyslipidemia and elevated ALT levels was 3.70％(175/4 725).The multivariate logistic regression analysis showed that after adjusting confounding factors,the dyslipidemia(OR=2.328,95％CI:1.775-3.053)and ALT elevation(OR=2.060,95％CI:1.363-3.114)were related to the increased risk of HUA.Interaction analysis showed that there was no multiplicative interaction between dyslipidemia and ALT elevation on HUA disease(OR=1.870,95％CI:0.943-3.710);but there was the additive interaction.The risk of HUA disease in the subjects with both of elevated ALT and dyslipidemia was 5.079 times higher than that in subjects without both of elevated ALT and dyslipidemia(OR=6.079,95％CI:4.459-8.287).After adjusting confounding factors,relative excess risk ratio,attribution ratio and index of interaction,and percentage of pure factor-attributable interactions were 3.392(95％CI:1.521-5.264),55.800％(95％CI:40.700％-70.900％),3.011(95％CI:1.921-4.721)and 66.787％(95％CI:43.972％-72.238％),respectively.Conclusion Dyslipidemia and elevated ALT may have additive interaction on HUA disease.Improving blood lipid and controlling ALT level may collaboratively prevent HUA.
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