Prospective cohort study of correlation between depressive symptoms and cardiopulmonary diseases among mid-aged and elderly in China
Objective To explore the association between depressive symptoms and cardiopulmonary diseases among middle-aged and elderly people in China,and provide the scientific basis for the prevention and treatment of cardiopulmonary diseases.Methods The data were from China Health and Retirement Longitudinal Study(CHARLS).In 2011,the baseline investigation was performed with the 10-item Center for Epidemiologic studies Depression Scale(CESD-10)to evaluate the depressive symptoms of the subjects,and the related data of demographic sociological,physical examination,health status,and lifestyle were collected.Cardiopulmonary disease outcome data were from follow-up data in 2018,and 8 356 subjects were finally included.Cox proportional hazards regression models were performed to analyze respectively the influence of depressive symptoms on cardiovascular disease,chronic pulmonary diseases,only one type of diseases or cardiopulmonary comorbidity among mid-aged and elderly.The used software was R V.1.4.Results Among 8 356 subjects,there were 3 608 cases(43.2％)with depressive symptoms at baseline investigation;in 2018,during the follow-up,there were 846 cases(10.1％)with cardiovascular disease,374 cases(4.5％)with chronic pulmonary disease,1 046 cases(12.5％)with just only one disease,and 87 cases(1.0％)with cardiopulmonary comorbidity.The results of the Cox model showed that after adjusting confounding factors,compared with those mid-aged and elderly people without depressive symptoms,the depressive symptoms were related to the high risk of cardiovascular disease(HR=1.16,95％CI:1.01-1.33),chronic pulmonary disease(HR=1.41,95％CI:1.14-1.74),just only one disease(HR=1.29,95％CI:1.14-1.47),respectively(P＜0.05).But the depressive symptoms were not related with the risk of cardiopulmonary comorbidity(P＞0.05).The stratified analysis results indicated that as compared with the middle-aged and elderly population without depressive symptoms,depressive symptoms were related with high risk of cardiovascular disease among the 45-64 years old group(HR=1.24),females(HR=1.25),and those with secondary or higher education levels(HR=1.29);depressive sympotoms were associated with high risk of chronic pulmonary disease among the 45-64 years old group(HR=1.44),males(HR=1.48),those with primary education(HR=1.42),those with secondary education or higher(HR=1.52),and urban subjects(HR=1.44);depressive symptoms were related with the high risk of only one disease in the 45-64 years old group(HR=1.37),males(HR=1.22),females(HR=1.35),those with primary education level(HR=1.31),those with secondary or higher levels(HR=1.44),and urban subjects(HR=1.28),rural subjects(HR=1.42),P＜0.05 or P＜0.01.But there was no relationship between depressive symptoms of subjects with different characteristics and cardiopulmonary comorbidity(P＞0.05).Conclusion Depressive symptoms are independent risk factors for cardiovascular disease and chronic pulmonary disease in middle-aged and elderly people.But there is no relationship between depressive symptoms and cardiopulmonary comorbidity.
Cardiovascular diseaseChronic pulmonary diseaseCardiopulmonary comorbidityDepression symptomsMiddle-aged and elderly people
NETL
NSTL
万方数据
