Relationship between body mass index/serum uric acid co-development trajectories and non-alcoholic fatty liver disease
Objective To determine the joint development trajectories of body mass index(BMI)and serum uric acid,and explore the correlation between different trajectory groups and non-alcoholic fatty liver disease(NAFLD),and provide the new ideas for primary prevention and control of NAFLD.Methods A total of 19 504 subjects who had undergone 3 or more routine physical examinations and met the inclusion criteria in the Health Management Center of the Second Affiliated Hospital of Dalian Medical University from January 2015 to December 2022 were selected as the subjects.Stata 15.1 software was used to establish the group-based dual-trajectory modeling for determining the joint development model of BMI and serum uric acid.Four trajectory groups were identified in males and females:persistent low BMI level with increase in serum uric acid at low level(group 1),persistent medium BMI level with increase in serum uric acid at low level(group 2),persistent medium BMI level with increase in scrum uric acid at high level(group 3),and persistent high BMI level with increase in serum uric acid at medium level(group 4).Cox proportional hazard regression model was used to evaluate the NAFLD risk in different trajectory groups.The used software was SPSS 25.0.Results The incidence densities were 27.49/103 person-years,85.71/103 person-years,133.89/103 person-years,and 221.19/103 person-years in trajectory groups 1-4 for males;the incidence densities order was 4.11/103 person-years,30.59/103 person-years,53.10/103 person-years,141.39/103 person-years in trajectory groups 1-4 for females.The results of Cox proportional hazard regression analysis showed that after adjusting baseline age,clinical indicators,baseline BMI and baseline serum uric acid,group 1 served as the reference group,the risk of NAFLD in group 2(HR=2.53),group 3(HR=3.32)and group 4(HR=5.22)of males increased,and the risk of NAFLD in group 2(HR=5.89),group 3(HR=7.81)and group 4(HR=20.58)of females increased(P＜0.01).Conclusion The longitudinal change trajectories of BMI and serum uric acid have different combination modes,and have different effects on the risk of NAFLD.A comprehensive evaluation of the development modes of BMI and serum uric acid is helpful to more accurately identify the high-risk population of NAFLD.
Body mass indexSerum uric acidNon-alcoholic fatty liver diseaseTrajectory model
NETL
NSTL
万方数据
