首页|脂质蓄积指数与我国中老年人群2型糖尿病发病关联的纵向研究

脂质蓄积指数与我国中老年人群2型糖尿病发病关联的纵向研究

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  • NETL
  • NSTL
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目的 了解中国中老年人群脂质蓄积指数(LAP)与2型糖尿病发病风险之间的关联,为2型糖尿病防治提供科学依据.方法 数据来源于中国健康与养老追踪调查(CHARLS)2011年和2015年数据,选择其中5 317名≥45岁且符合纳入排除标准的中老年人为研究对象,进行问卷调查、体格检查和实验室检测.根据LAP(男性)=[腰围(cm)-65]×甘油三酯(mmol/L),LAP(女性)=[腰围(cm)-58]×甘油三酯(mmol/L)计算研究对象LAP.采用SPSS 20.0软件进行t检验和x2检验,采用R 4.2.3软件进行限制性立方样条函数(RCS)分析LAP与2型糖尿病发病风险之间的非线性关系,采用多因素logistic回归分析LAP与2型糖尿病发病风险的关联.结果 2015年随访调查时,共有492人(9.3％)被诊断为2型糖尿病.RCS分析结果显示,LAP与2型糖尿病发病风险之间呈现非线性关系,全人群LAP＞25.553时、男性LAP＞19.055或女性LAP＞31.127时,2型糖尿病发病风险显著上升.多因素logistic回归分析结果显示,校正混杂因素后,全人群中与LAP较低组(≤25.553)相比,较高组(＞25.553)2型糖尿病发病风险上升了145％(OR=2.45,95％CI:1.97～3.05).男性中与LAP较低组(≤19.055)相比,较高组(＞19.055)2型糖尿病发病风险上升了71％(OR=1.71,95％C/:1.25～2.34).女性中与LAP较低组(≤31.127)相比,较高组(＞31.127)2型糖尿病发病风险上升了217％(OR=3.17,95％CI:2.31～4.35).结论 LAP对中国中老年人群2型糖尿病发病风险具有一定的指示作用,可将其纳入中老年人群2型糖尿病早期风险监测指标体系.
Correlation between lipid accumulation product and type 2 diabetes mellitus among middle-aged and elderly people in China
Objective To explore the correlation between lipid accumulation product(LAP)and the risk of type 2 diabetes mellitus(T2DM)among middle-aged and elderly people,and provide the scientific basis for prevention and treatment of T2DM.Data were from the China Health and Retirement Longitudinal Study(CHARLS)2011 and 2015,5 317 residents(≥45 years old)meeting the inclusion and exclusion criteria were selected as the subjects.The investigation was performed with questionnaire,physical examination and lab test.According to LAP(male)=[WC(cm)-65]×TG(mmol/L)and LAP(female)=[WC(cm)-58]×TG(mmol/L),the LAP of subjects were calculated.The t test and x2 test were used to analyze the data,the used software was SPSS 20.0;R 4.2.3 software was utilized for restrictive cubic spline(RCS)function to analyze the non-linear relationship between LAP and risk of T2DM.Multivariate logistic regression was used to analyze the correlation between LAP and risk of T2DM.Results At the follow-up survey in 2015,492 subjects(9.3％)were diagnosed with T2DM.RCS analysis showed that there was the non-linear correlation between LAP and the risk of T2DM,when all LAP was＞25.553,male LAP was＞19.055 and male LAP was＞31.127,the risk of T2DM increased significantly.Multivariate logistic regression showed that after adjusting for the confounding factors,as compared with the lower LAP group(≤ 25.553),the T2DM risk of higher LAP group(＞25.553)increased by 145％(OR=2.45,95％CI:1.97-3.05)in all people;as compared with male lower LAP group(≤19.055),the T2DM risk of male higher LAP group(＞19.055)increased by 71％(OR=1.71,95％CI:1.25-2.34);as compared with female lower LAP group(≤31.127),the T2DM risk of female higher LAP group(＞31.127)increased by 217％(OR=3.17,95％CI:2.31-4.35).Conclusion LAP has some indicating role of T2DM risk among middle-aged and elderly people,LAP may be included in monitoring index system for early T2DM risk among middle-aged and elderly people.

Middle-aged and elderly peopleLipid accumulation productDiabetes mellitus,type 2Cohort study

夏弋钦、连真、杨华

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上海中医药大学附属龙华医院内分泌科,上海 200032

中老年 脂质蓄积指数 糖尿病,2型 队列研究

2024

10.16386/j.cjpccd.issn.1004-6194.2024.04.003

中国慢性病预防与控制
中华预防医学会,天津市疾病预防控制中心

中国慢性病预防与控制

CSTPCD北大核心
影响因子：1.093
ISSN：1004-6194
年,卷(期)：2024.32(4)
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