Interaction of overweight,obesity and hypertension on B stage heart failure
Objective To understand the influence of interaction of overweight,obesity and hypertension on risk of B stage heart failure,and provide the scientific basis for scientific and rational prevention or delay of heart failure condition.Methods Data were from the epidemiological investigation of heart failure in Shenzhen city,and the stratified random sampling method was used to select 6 080 residents(≥ 18 years old)as the subjects.The investigation was performed with information questionnaire,physical measurement and echocardiogram examination.Logistic regression model was used to analyze the influence of overweight,obesity and hypertension on B stage heart failure.Multiplication and additive model was used to analyze the interaction between overweight,obesity and hypertension.Relative excess risk due to interaction(RERI),attributable proportion due to interaction(API)and synergy index(SI)were calculated.The x2 test was used to analyze the data,the used software was R 4.2.1.Results Among 6 080 subjects,there were 940 cases with B stage heart failure(15.46％),1 650 cases with hypertension(27.14％),1 985 cases with overweight(32.65％),and 734 cases with obesity(12.07％).The multivariate logistic regression analysis showed that after adjusting the confounding factors,there was no multiplicative interaction between overweight,obesity and hypertension(overweight:OR=1.36,95％CI:0.95-1.94,obesity:OR=1.37,95％CI:0.90-2.09).There was the positive additive interaction between overweight,obesity and hypertension on the risk of B stage heart failure;RERI,API and SI of interaction between overweight and hypertension were 0.98(95％CI:0.31-1.65),0.33(95％CI:0.14-0.51)and 1.97(95％CI:1.17-3.30),respectively;RERI,API and SI of interaction between obesity and hypertension were 2.41(95％CI:0.66-4.16),0.37(95％CI:0.17-0.58)and 1.81(95％CI:1.19-2.74),respectively.Conclusion There may be an additive interaction between overweight,obesity and hypertension,and simultaneous control of hypertension and body mass index(BMI)at normal levels may synergistically prevent or delay the development of B stage heart failure.
Body mass indexHypertensionHeart failureInteraction
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NSTL
万方数据
