Correlation between triglyceride-glucose index and risk of all-cause death or cardiovascular disease death in urban and rural elderly of Beijing
Objective To explore the correlation between triglyceride-glucose(TyG)index and risk of all-cause death or cardiovascular disease death(CVD)in urban and rural elderly of Beijing,provide the scientific basis for clarifying the correlation of TyG index and all-cause mortality and cardiovascular mortality in the elderly.Methods The data were from Beijing Elderly Comprehensive Health Cohort Study(BECHCS).In 2009-2010 and 2014,the elderly residents(≥60 years old)in Wanshou Road street of Haidian district and Miyun district in Beijing were selected as the subjects.Follow-up was performed until March 31,2021,a total of 4 499 eligible elderly people in urban and rural communities in Beijing were included.ANOVA and x2 test were used to analyze the data.The used software was SPSS 26.0 and R 4.0.3.A Cox proportional hazards regression model was used to analyze the correlation between the TyG index as a continuous variable and quintile and all-cause mortality or CVD mortality.Results The mean age of 4 499 subjects was(70.5±6.8)years old,1 814(40.3％)male and 2 685(59.7％)female;including 2 397(53.3％)rural elderly and 2 102(46.7％)urban elderly.The TyG index was included as a continuous variable in the Cox proportional hazards regression model.The results showed that after adjusting for the confounding factors,in the total population,when per 1 unit of TyG increased,the risk of all-cause mortality increased by 24.2％(HR=1.242,95％CI:1.082-1.427),and the risk of CVD mortality increased by 43.4％(HR=1.434,95％CI:1.091-1.886).In rural elderly,when per 1 unit of TyG increased,the risk of all-cause mortality increased by 34.9％(HR=1.349,95％CI:1.093-1.664),and the risk of CVD mortality increased by 62.6％(HR=1.626,95％CI:1.098-2.427).In elderly(≥80 years old),or males and females,when per 1 unit of TyG increased,the risk of all-cause death increased by 62.1％(HR=1.621,95％CI:1.216-2.160),27.8％(HR=1.278,95％CI:1.046-1.562),24.3％(HR=1.243,95％CI:1.022-1.510);and CVD risk increased by 76.2％(HR=1.762,95％CI:1.050-2.959),68.2％(HR=1.682,95％CI:1.158-2.443)and 80.2％(HR=1.802,95％CI:1.054-2.140),respectively.When TyG index was included in the model according to five categorical variables,after adjusting for the confounding factors,in total elderly,the risk of all-cause mortality and CVD mortality in Q5 group was significantly higher than that inQ1group(HR=1.462,95％CI:1.114-1.919;HR=2.350,95％CI:1.336-4.133).Conclusion In rural and urban elderly,the TyG index correlated to increased risk of all-cause death and CVD death.TyG index can be used as a reference indicator for mortality risk prediction in community-dwelling older adults.
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万方数据
