A cohort study of the correlation between serum prealbumin levels and all-cause mortality in rural elderly in Miyun district of Beijing
Objective To understand the correlation between serum prealbumin levels and all-cause mortality in rural elderly in Miyun district of Beijing,and provide the relevant suggestion for reducing the risk of all-cause mortality in elderly.Methods Data were from the baseline and follow-up data in the rural areas of the Beijing Elderly Comprehensive Health Cohort Study(BECHCS).A two-stage random sampling method was used to select 2 090 elderly residents(≥60 years old)as the subjects from June to September 2014 in Jugezhuang town and Fengjiayu town of Miyun district in Beijing.The investigation was performed with questionnaires,physical examination and laboratory tests;and follow-up visits were conducted every 2-3 years until March 31,2021.The variance analysis and x2 test were used to analyze the data,the used software was SPSS 26.0.Survival curves were plotted using the Kaplan-Meier method,and differences in survival curves were compared using the log-rank test.The multifactorial Cox proportional risk regression models was used to analyze the correlation between serum prealbumin levels and all-cause mortality.Results Serum prealbumin level was(274.83±56.98)mg/L and all-cause mortality density was 16.74/1 000 person-years in 2 090 rural elderly.Multifactorial Cox proportional risk regression analysis showed that low serum prealbumin was a risk factor for all-cause mortality in the elderly(HR=1.409,95％CI:1.056-1.880),P＜0.05.Sex-stratified analysis showed that low serum prealbumin level was a risk factor for all-cause mortality(HR=2.074,95％CI:1.444～2.980)in male elderly,P＜0.05;but there was no significant correlation between serum prealbumin level and all-cause mortality in female elderly,P＞0.05.Conclusion Elderly people with low serum prealbumin levels in the rural community of Miyun district in Beijing have a higher risk of all-cause mortality.Focused interventions and management should be conducted in the elderly population to reduce the risk of all-cause mortality.
NETL
NSTL
万方数据
