Visual analysis of research hotspot and trend of familial hypercholesterolemia in China based on CiteSpace
Objective To explore the research hotspots and development trend of familial hypercholesterolemia(FH)in China,and provide the scientific basis for further research of FH.Methods Chinese literatures with FH as the title or theme published in China National Knowledge Infrastructure(CNKI),WangFang and VIP from 2004 to 2023 were searched,and software CiteSpace 6.3.R1 was used to draw the correlation maps of keywords,and analyze the distribution of major research institutions and authors in the fiield,and explore the research frontiers and hotspots in the field.Results There were 430 FH related Chinese literatures which were included in the study.And the number of published papers showed an overall increasing trend(R2=0.508).Top 3 institutions with the most publications were Beijing Anzhen Hospital,University of South China and Peking Union Medical College Hospital,the top 3 authors with the most publications were Wang Luya,Lin Jie and Yang Ya.The research hotspots of Chinese scholars on FH mainly focused on pathogenesis(genes),disease manifestation(coronary heart disease,xanthoma),diagnosis and treatment.The top 5 keywords by frequency of occurrence were"gene mutation","familial","coronary heart disease","xanthoma",and"treatment".The top 5 keywords by centrality were"gene mutation"(centrality of 0.67),"familial"(centrality of 0.39),"mutation"(centrality of 0.31),"coronary heart disease"(centrality of 0.27),and"genotype"(centrality of 0.20).The regional distribution of FH research institutions varied greatly,and most of them were distributed in northern cities.Genetic research was still a hot spot in the future.Conclusion The research on FH in China is in a period of rapid development,and the visual analysis method can intuitively show the research hotspots and trend of FH in recent years,and provide the reference for promoting the research progress of FH and reducing the health hazards caused by FH.
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