Correlation of serum ferritin and cardiometabolic index with peripheral atherosclerotic disease in patients with type 2 diabetes mellitus
Objective To explore the correlation of serum ferritin(SF)combined with cardiometabolic index(CMI)and peripheral atherosclerosis(AS)in patients with type 2 diabetes mellitus(T2DM),and provide the guidance for the clinical diagnosis and treatment of vascular diseases in T2DM patients.Methods Total of 1 246 T2DM patients hospitalized in the department of endocrinology of the First Hospital of Lanzhou University from June 2020 to July 2023 were selected as the subjects.According to the ultrasound results of bilateral carotid and bilateral lower limb arteries,the subjects were divided into two groups(with peripheral AS group and without peripheral AS group),then the differences of SF and CMI levels between the two groups were compared.According to SF level,the subjects were divided into high ferritin(HF)group and Non-HF group,and according to CMI quartile level,they were divided into Q1-Q4 groups,and the differences in the prevalence of peripheral AS and the levels of brachial and ankle pulse wave velocity(baPWV)were compared among the groups.Independent samples t test,one-way analysis of variance,Mann-Whitney U test,Kruskal-Wallis H test andx2 test were used to analyze the data,the multifactor binary logistic regression was used to analyze the correlation between SF or CMI and the occurrence of peripheral AS;and the receiver operating characteristic(ROC)curves were used to analyze the effect of SF combined with CMI on the diagnostic value of the peripheral AS occurrence in T2DM patients.The used software was SPSS 26.0.Results The SF level in the peripheral AS group was 187.00 μg/L(P25-P75:106.00-369.50 μg/L),and the CMI level was 0.93(P25-P75:0.61-1.56),which were higher than those(150.00 μg/L,P25-P75:79.70-249.00 μg/L and 0.74,P25-P75:0.46-1.25)in the group without peripheral AS,P＜0.05.The morbidity(74.0％)of peripheral AS and the morbidity(67.9％)of neck AS in the HF group were significantly higher than those(61.2％and 56.4％)in the Non-HF group,respectively,P＜0.05.The AS morbidities of periphery,neck and lower limbs increased with CMI level in T2DM patients(x2trend values were 22.391,10.449 and 9.292,Ptrend＜0.05);left and right baPWV levels showed upword trend(β values were 0.080 and 0.064,Ptrend＜0.05);left baPWV level in Q4 group was 18.28 m/s,P25-P75:15.71-21.07 m/s,which was significantly higher than that(17.14 m/s,P25-P75:15.04-19.77 m/s)inQ1group,P＜0.05.After adjusting for the confounding factors,multifactorial binary logistic regression analysis showed that the levels(OR=1.003,95％CI:1.002-1.004;OR=1.389,95％CI:1.137-1.696)of SF and CMI were correlated to high risk of peripheral AS in T2DM patients(P＜0.05).ROC curves analysis showed that SF combined with CMI could improve the diagnostic value for the occurrence of peripheral AS disease in T2DM patients,the area under the ROC curve(AUC)was 0.758(95％CI:0.724-0.792,P＜0.05).Conclusion The elevated levels of SF and CMI are associated with the high risk of peripheral AS in T2DM patients,and SF combined with CMI can improve the diagnostic value of the occurrence of peripheral AS disease in T2DM patients.
NETL
NSTL
万方数据
