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糖皮质激素对免疫细胞调控的研究进展

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免疫系统是重要的人体健康卫士,免疫系统失调是引发各种疾病的源头,免疫防御和免疫监视调控能力的降低导致病原体和恶变细胞难以及时清除,从而增加了致病概率和病死风险.科学研究已经证实压力过大是导致免疫系统失调的重要因素,已在动物模型和人体中发现,压力加大会提高体内神经内分泌激素的水平,尤其是糖皮质激素和儿茶酚胺,而且应激激素对免疫功能产生诸多不利影响.本综述重点梳理糖皮质激素对免疫细胞的调控研究进展.
Research progress on regulation of glucocorticoids on immune cells
The immune system is the defender of human health,whose dysregulation is the source of various diseases.Re-duced immune defense and immune surveillance capabilities lead to difficulties in removing pathogens and malignant cells,thus increasing morbidity and mortality risk.Stress is a major factor in the decline of the immune system.In past studies,it has been demon-strated both in animal and humans that stress increases the levels of neuroendocrine hormones in the body,particularly glucocorticoids and catecholamines.Through the action of these stress hormones,stress has a number of detrimental effects on immune function,and this review combs through the progress of research on the regulation of immune cells by glucocorticoids.

StressImmunityGlucocorticoids

李佳荣、张纪岩

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南华大学药学院,南华大学药物药理研究所,衡阳 421001

军事科学院军事医学研究院军事认知与脑科学研究所,北京 100850

压力 免疫力 糖皮质激素

2024

中国免疫学杂志
中国免疫学会,吉林省医学期刊社

中国免疫学杂志

CSTPCD北大核心
影响因子:0.926
ISSN:1000-484X
年,卷(期):2024.40(1)
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