糖皮质激素对免疫细胞调控的研究进展
Research progress on regulation of glucocorticoids on immune cells
李佳荣 1张纪岩2
作者信息
- 1. 南华大学药学院,南华大学药物药理研究所,衡阳 421001
- 2. 南华大学药学院,南华大学药物药理研究所,衡阳 421001;军事科学院军事医学研究院军事认知与脑科学研究所,北京 100850
- 折叠
摘要
免疫系统是重要的人体健康卫士,免疫系统失调是引发各种疾病的源头,免疫防御和免疫监视调控能力的降低导致病原体和恶变细胞难以及时清除,从而增加了致病概率和病死风险.科学研究已经证实压力过大是导致免疫系统失调的重要因素,已在动物模型和人体中发现,压力加大会提高体内神经内分泌激素的水平,尤其是糖皮质激素和儿茶酚胺,而且应激激素对免疫功能产生诸多不利影响.本综述重点梳理糖皮质激素对免疫细胞的调控研究进展.
Abstract
The immune system is the defender of human health,whose dysregulation is the source of various diseases.Re-duced immune defense and immune surveillance capabilities lead to difficulties in removing pathogens and malignant cells,thus increasing morbidity and mortality risk.Stress is a major factor in the decline of the immune system.In past studies,it has been demon-strated both in animal and humans that stress increases the levels of neuroendocrine hormones in the body,particularly glucocorticoids and catecholamines.Through the action of these stress hormones,stress has a number of detrimental effects on immune function,and this review combs through the progress of research on the regulation of immune cells by glucocorticoids.
关键词
压力/免疫力/糖皮质激素Key words
Stress/Immunity/Glucocorticoids引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据