摘要
免疫性皮肤病指一类免疫系统介导的自身免疫性或炎症性皮肤病,包括红斑狼疮、银屑病、特应性皮炎和白癜风等.免疫性皮肤病发病机制仍不明确,疾病进程复杂,临床表现多样,治疗困难,给免疫性皮肤病的诊断和治疗带来了巨大挑战.近年来,我国皮肤病学研究者在免疫性皮肤病方面取得了许多创新性研究成果.近10年中国学者在免疫性皮肤病领域发表SCI论文11 919篇,其中10余篇发表在顶级期刊,包括发表在科学(Science)1篇、自然(Nature)1篇、细胞(Cell)2篇、新英格兰医学杂志(New England Journal of Medicine)3篇、柳叶刀(The Lancet)2篇、自然医学(Nature Medicine)1篇及免疫(Immunity)4篇等.本文主要就我国在免疫性皮肤病发病机制、诊断及治疗方式等方面的研究进展进行总结.
Abstract
Immunologic skin diseases encompass a spectrum of immune system-mediated autoimmune or inflammatory skin conditions,such as lupus erythematosus,psoriasis,atopic dermatitis,and vitiligo.Immunologic skin diseases are characterized by an unclear pathogenesis,complex disease processes,diverse clinical manifestations,and treatment difficulties,thereby presenting sig-nificant diagnostic and therapeutic challenges.Notably,Chinese researchers have achieved numerous innovative research findings on immunologic skin diseases in recent years.Over the past decade,Chinese scholars have contributed 11 919 SCI papers to the field of immune dermatosis,with more than 10 being published in the world's leading medical journals.These publications include one in Sci-ence,one in Nature,two in Cell,three in The New England Journal of Medicine,two in The Lancet,and one in Nature Medicine,as well as four in Immunity.Here,we aim to present a comprehensive summary of Chinese research progress pertaining to the pathogene-sis,diagnosis and treatment of immunologic skin diseases.
基金项目
国家科技重大专项(2020ZX09201-28)
中国医科院医学与健康科技创新工程(CIFMS)项目(2019-2M-5-033)
国家科技期刊平台
NSTL
维普
万方数据