摘要
新型冠状病毒肺炎(COVID-19)感染性强,且重型及危重型患者病死率高,缺乏特异性治疗方法,急需寻找安全有效的治疗方法.间充质干细胞(MSCs)具有免疫调节、组织修复、再生、迁移和归巢、抗病毒和抗炎等生物学特性.目前应用MSCs治疗COVID-19的研究已逐步开展.本文就2019新型冠状病毒(2019-nCoV)的致病机制、MSCs治疗COVID-19的潜在机制及面临的挑战进行综述.
Abstract
Coronavirus disease 2019(COVID-19)is highly infectious,severe and critically ill patients have high mortality and lack specific treatment,so it is urgent to find safe and effective treatment methods.Mesenchymal stem cells(MSCs)have biologi-cal properties such as immune regulation,tissue repair,regeneration,migration and homing,antiviral and anti-inflammatory.At present,studies on use of MSCs in treatment of COVID-19 have been gradually carried out.This paper reviews pathogenesis of 2019 novel coronavirus(2019-nCoV),potential regulatory mechanisms and challenges of MSCs in treatment of COVID-19.
国家科技期刊平台
NSTL
维普
万方数据