miR-155/GATA3/CD4+T细胞通路对变应性鼻炎发病机制的调控
miR-155/GATA3/CD4+T cell pathway regulates pathogenesis of allergic rhinitis
李荣荣 1瞿申红 2张少杰 2黄雪颖 2钟自玲2
作者信息
- 1. 右江民族医学院,百色 533000;广西壮族自治区人民医院耳鼻咽喉头颈科,南宁 530021;榆林市星元医院,榆林 719000
- 2. 广西壮族自治区人民医院耳鼻咽喉头颈科,南宁 530021
- 折叠
摘要
变应性鼻炎(AR)指具有特异性体质的个体第二次接触相同致敏原后立即触发由免疫球蛋白E介导的Ⅰ型变态反应,其发病机制尚未明确,与多种基因、免疫细胞、细胞因子等密切相关.随着分子生物学和第二代基因测序技术快速发展,AR发病机制研究逐步深化、精准.研究发现miR-155和转录因子GATA3对AR发生发展有重要调控作用,进而影响CD4+T淋巴细胞的优势分化趋势和ILC2增生.本文主要以miR-155/GATA3通路为中心,探讨相关上游基因和下游调控物质对AR发病机制的影响并进行综述.
Abstract
Allergic rhinitis(AR)is a type Ⅰ allergic reaction,which mediated by immunoglobulin E immediately when an individual with a special constitution is exposed to a same allergen for second time,whose pathogenesis has not been clarified yet,and closely related to genes,immune cells and cytokines.Pathogenesis of AR become more deeper and more accurate due to rapid develop-ment of molecular biology and second-generation gene sequencing technology.Current studies have found that miR-155 and transcrip-tion factor GATA3 have important regulatory effects on occurrence and development of AR,then affect dominant differentiation of CD4+T lymphocytes and proliferation of ILC2.This article discusses and reviews pathogenesis of AR,which mainly focuses on miR-155/GATA3 pathway and effects of related upstream genes and downstream regulatory substances.
关键词
变应性鼻炎/miR-155/GATA3/CD4+T细胞/ILC2Key words
Allergic rhinitis/miR-155/GATA3/CD4+T cell/ILC2引用本文复制引用
基金项目
国家自然科学基金地区科学基金(81960186)
出版年
2024
国家科技期刊平台
NSTL
万方数据