补体凝集素与呼吸系统疾病
Complement lectins and respiratory diseases
王世雄 1聂浩 2张昊川 1黄河1
作者信息
- 1. 安徽医科大学深圳二院临床学院,深圳市第二人民医院呼吸与危重症医学科,深圳 518035
- 2. 长江大学医学部,荆州 434023
- 折叠
摘要
补体凝集素途径是补体系统激活的一种途径,纤维胶凝蛋白(ficolin)与甘露糖结合凝集(MBL)是激活免疫补体途径的一类起始物,两者结构及功能极其相似,可通过识别病原表面的某些物质,激活补体,加强调理吞噬作用或直接杀灭和溶解相关病原,从而在免疫系统中尤其在抗感染方面发挥重要作用.呼吸系统疾病多以感染性疾病为主.近年来,也有相关研究报道ficolin/MBL与众多其他呼吸系统疾病具有相关性,本文就ficolin/MBL与呼吸系统疾病的相关研究进行综述,以期为相关研究提供理论支撑.
Abstract
The complement lectin pathway is an important means to exert immune effect.Ficolin and Mannan-binding lectin(MBL)are the initiators of complement pathway.Both structure and function are very similar.They can activate the complement path-way by recognizing certain substances on the surface of pathogens,emphasizing phagocytosis or directly kill and dissolve related patho-gens,thereby playing an important role in the immune system,especially in fighting infection.The respiratory system diseases are mostly infectious diseases.In recent years,there have been reports that ficolin/MBL is related to many other respiratory diseases.This article discusses the related research of ficolin/MBL and respiratory diseases,hopes to provide theoretical support for related research.
关键词
纤维胶凝蛋白/甘露糖结合凝集素/补体/呼吸系统疾病Key words
Ficolin/Mannose-binding lectin/Complement/Respiratory diseases引用本文复制引用
基金项目
国家自然科学基金(31502059)
广东省高水平医院深圳市第二人民医院临床研究项目(20193357024)
出版年
2024
国家科技期刊平台
NSTL
万方数据