细胞因子在结缔组织病相关间质性肺病发病机制中的作用研究进展
Research progress on role of cytokines in pathogenesis of connective tissue disease-associated interstitial lung disease
刘一平 1颜菲 1张榕1
作者信息
- 1. 中国医科大学附属第一医院,沈阳 110001
- 折叠
摘要
间质性肺病(ILD)是结缔组织病(CTD)常见肺部并发症之一,严重影响CTD患者生存质量并明显增加患者死亡风险,而CTD-ILD相关免疫机制尚不明确.本文系统综述并回顾多种细胞因子如何参与CTD-ILD发病,从细胞水平、动物模型及临床试验等多角度论述细胞因子在CTD-ILD中的发病机制及其与临床指标的关系,探讨细胞因子作为CTD-ILD治疗靶标的可能性,以指导未来相关研究并为临床实践提供参考.
Abstract
Interstitial lung disease(ILD)is one of common pulmonary complications of connective tissue disease(CTD),which seriously affects quality of life and significantly increases risk of death of patients with CTD.However,related immune mecha-nism of CTD-ILD is not clear yet.This paper systematically reviews involvement of various cytokines in pathogenesis of CTD-ILD.Pathogenesis of CTD-ILD and correlation between cytokines and clinical indicators were discussed from cell level,animal model and clinical trials,to investigate whether cytokines can be targeted for treatment of CTD-ILD to help guide future research and clinical practice.
关键词
结缔组织病/间质性肺病/细胞因子Key words
Connective tissue disease/Interstitial lung disease/Cytokines引用本文复制引用
基金项目
辽宁省自然科学基金(20180550997)
出版年
2024
国家科技期刊平台
NSTL
万方数据