Research progress of costimulatory signals and cardiovascular diseases
Chronic inflammation is the pathological basis for the development of cardiovascular diseases.Immune cells domi-nated by T cells can secrete pro-inflammatory factors to mediate inflammation and affect the progress of cardiovascular diseases.The co-stimulatory signals is the second signal of T cell activation,which can enhance or inhibit the signal transmission of T cell antigen re-ceptor(TCR)by Phosphatidylinositol 3-kinase(PI3K),mitogen activated protein kinase(MAPK)and C-Jun N-terminal kinases(JNK),which play an important role in cardiovascular disease by regulating T cell immune function,the release of inflammatory cyto-kines,and the production of extracellular matrix.This article describes the transmission mechanism of costimulatory signals and their correlation with cardiovascular diseases,in order to provide new ideas for immunotherapy of cardiovascular diseases.
国家科技期刊平台
NSTL
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