MicroRNA调节免疫性血小板减少症CD4+T细胞亚群免疫功能的研究进展
Research progress of microRNA-mediated immune function of CD4+T cells subsets in immune thrombocytopenia
宋辉 1郭一慧 1许家威 1曾清 2程纬民2
作者信息
- 1. 广西中医药大学研究生院,南宁 530222
- 2. 广西中医药大学研究生院,南宁 530222;广西中医药大学第一附属医院血液内科,南宁 530023
- 折叠
摘要
MicroRNA(miRNA)是一种小分子非编码单链RNA,可广泛参与多种生物学过程,对调节机体的免疫功能具有重要作用.免疫性血小板减少症(ITP)是一种自身免疫性疾病,其发生和进展与miRNA介导CD4+T细胞亚群的异常免疫调节密切相关.ITP患者miRNA的不同表达情况可影响CD4+T细胞亚群的免疫功能,导致Th1/Th2、Th17/Treg的调节失衡和TFH的过度分化,引起细胞因子分泌异常.本文就ITP中miRNA介导的CD4+T细胞亚群免疫功能失衡机制进行总结,以期为探索ITP的免疫机制和免疫治疗提供启发.
Abstract
MicroRNA(miRNA)is a kind of small non-coding single stranded RNA that can participate in multiple biological processes.It also plays an important role in regulating the immune function of the body.Immune thrombocytopenia(ITP)is an autoim-mune disease,whose cause and deterioration are closely related to miRNA regulates immune function of CD4+T cells subsets.In ITP patients,different expression of miRNA can affect the immune function of CD4+T cells subsets,which causes not only unbalanced ex-pression of Th1/Th2,Th17/Treg and excessive differentiation of TFH,but also abnormal cytokine secretion furthermore.This paper summarizes the unbalanced mechanism of miRNA regulating immune function of CD4+T cells subsets in ITP,so as to provide inspira-tion for exploring the immunology and immunotherapy of ITP.
关键词
MicroRNA/免疫性血小板减少症/CD4+T细胞亚群Key words
MicroRNA/Immune thrombocytopenia/CD4+T cells subsets引用本文复制引用
基金项目
广西自然科学基金(2018GXNSFAA281082)
广西中医药大学强基计划(XYJB074)
出版年
2024
国家科技期刊平台
NSTL
万方数据