FGL2在胃肠间质瘤的表达及临床意义
Expression and clinical significance of FGL2 in GIST
张向莲 1王兴芬 1梁锐1
作者信息
- 1. 天津医科大学第二医院病理科,天津 300211
- 折叠
摘要
目的:探讨纤维蛋白原样蛋白2(FGL2)在胃肠道间质瘤(GIST)中的表达及临床意义.方法:运用免疫组化EnVision二步法检测158例GIST患者中FGL2蛋白的表达情况,分析其与临床病理参数之间的相关性,并探讨FGL2蛋白与GIST中肿瘤浸润性淋巴细胞(TILs)CD3+T、CD8+T、CD20+T及CD68+T细胞计数之间的关系.结果:FGL2蛋白在GIST中的表达与肿瘤大小、NIH危险度分级、坏死及核分裂象计数呈负相关(P<0.05),与患者性别及肿瘤发生部位差异无统计学意义(P>0.05).在GIST中,FGL2表达与低CD3+T细胞计数相关(P<0.05),而与CD8+T、CD20+T及CD68+T细胞计数差异无统计学意义(P>0.05).结论:FGL2蛋白参与GIST的发生和发展,其表达水平在一定程度上可预测GIST的恶性潜能.FGL2蛋白可能通过调节肿瘤微环境参与GIST的发生和发展.
Abstract
Objective:To explore the expression and clinical significance of fibrinogen-like protein 2(FGL2)in gastrointesti-nal stromal tumor(GIST).Methods:Immunohistochemical EnVision two-step method was used to detect expression of FGL2 protein in 158 GIST patients,and correlation between FGL2 protein and clinicopathological parameters was analyzed,and relationship be-tween FGL2 protein and the count of CD3+T,CD8+T,CD20+T and CD68+T of tumor-infiltrating lymphocytes(TILs)in GIST was inves-tigated.Results:Expression of FGL2 protein in GIST was negatively correlated with tumor size,NIH risk grade,necrosis and mitotic image count(P<0.05),there was no significant difference in gender and tumor location(P>0.05).FGL2 expression was associated with low CD3+T cell counts in GIST(P<0.05),while there was no significantly difference with CD8+T,CD20+T and CD68+T cell counts(P>0.05).Conclusion:FGL2 protein is involved in occurrence and development of GIST,which expression level is partly pre-dictive of the malignant potential of GIST.FGL2 protein may participate in occurrence and development of GIST by regulating tumor microenvironment.
关键词
纤维蛋白原样蛋白2/胃肠道间质瘤/肿瘤浸润相关淋巴细胞Key words
Fibrinogen-like protein 2/Gastrointestinal stromal tumor/Tumor infiltration of associated lymphocytes引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据