炎症细胞因子与不同特征重性抑郁障碍的相关性
Correlation of inflammatory cytokines with different characteristics of major depressive disorder
闵雪 1王彦芳 2姚红 1张云巧2
作者信息
- 1. 山西医科大学基础医学院微生物与免疫学教研室,太原 030000
- 2. 山西医科大学第一附属医院精神卫生科,太原 030000
- 折叠
摘要
目的:探讨血清炎症细胞因子与不同特征重性抑郁障碍的相关性.方法:ELISA检测血清炎症细胞因子,比较忧郁/动力不足特征(MPD)组、焦虑/躯体特征(ASD)组和健康对照(HC)组之间血清炎症细胞因子的差异.Spearman法分析炎症细胞因子与HAMD-17总分及各项因子分的相关性,二元Logistic回归分析测定不同特征重性抑郁障碍的独立危险因素.结果:与HC组和ASD组比较,MPD组血清IFN-α、IL-6水平升高(P<0.05);MPD组血清TNF-α水平与认知障碍因子分呈负相关(P<0.05),ASD组血清TNF-α水平与认知障碍因子分呈负相关(P<0.05),IL-6水平与睡眠障碍因子分呈负相关(P<0.05).结论:炎症细胞因子与不同特征重性抑郁障碍的症状关联,IFN-α、TNF-α、IL-6、IL-10是忧郁/动力不足重性抑郁障碍的独立危险因素.IFN-α、IL-6可能作为区分忧郁/动力不足和焦虑/躯体重性抑郁障碍的客观生物标志物.
Abstract
Objective:To investigate the correlation between serum inflammatory cytokines and different characteristics of major depressive disorder.Methods:Serum inflammatory cytokines were detected by ELISA,compared differences of serum inflamma-tory cytokines in melancholy/underpowered depression(MPD)group,anxiety/somatization depression(ASD)group and healthy con-trol(HC)group.Spearman was used to analyze the correlation between inflammatory cytokines and HAMD-17 total score and each fac-tor score,independent risk factors for major depressive disorder with different characteristics were analyzed by binary Logistic regres-sion.Results:Compared with HC group and ASD group,serum IFN-α and IL-6 levels in MPD group were increased(P<0.05);level of serum TNF-α was negatively correlated with the score of cognitive impairment in MPD group(P<0.05),level of serum TNF-α was negatively correlated with the score of cognitive impairment in ASD group(P<0.05),and level of IL-6 was negatively correlated with the score of sleep disorder(P<0.05).Conclusion:Inflammatory cytokines are associated with symptoms of different characteristics of major depressive disorder;IFN-α,TNF-α,IL-6 and IL-10 are independent risk factors for melancholy/underpowered major depres-sive disorder,and IFN-α and IL-6 may serve as objective biomarkers to distinguish melancholy/underpowered from anxiety/somatiza-tion major depressive disorder.
关键词
炎症细胞因子/免疫/重性抑郁障碍/忧郁/动力不足特征/焦虑/躯体特征Key words
Inflammatory cytokines/Immune/Major depressive disorder/Melancholy/underpowered/Anxiety/somatization引用本文复制引用
基金项目
国家重点研发项目(2016YFC1307103)
山西省136兴医工程项目(Y2022136012)
山西省应用基础项目(201801D121345)
山西省卫生健康委科研基金项目(2022140)
出版年
2024
国家科技期刊平台
NSTL
万方数据