首页|多种代谢物与巨噬细胞极性调节研究进展

多种代谢物与巨噬细胞极性调节研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
巨噬细胞是最重要的一类固有免疫细胞,功能多样性和极化可塑性是其重要特征.从极化角度,巨噬细胞可大致分为具有杀伤病原体和肿瘤细胞,并具有较强促炎因子生成能力的M1型;或以表达抑炎因子、促进组织修复和血管生成为主要特征的M2型.并且,巨噬细胞能够根据生理变化或疾病演进过程主动调节自身信号,使其向不同方向极化或重塑,从而趋向形成不同功能和不同表型的巨噬细胞.代谢物是最重要的基本生理病理活动特征的外部因素之一,然而生理变化或疾病演进过程中,代谢物对巨噬细胞极性重塑的影响还有待归纳总结.因此,本综述以外泌代谢物或外泄的胞内代谢物为切入点,系统地总结不同代谢物对巨噬细胞极化的影响和作用机制,并梳理出多种疾病病理微环境存在的代谢物变化对巨噬细胞极化的影响及其对疾病进展的作用,旨在从多因素、多维度角度探讨细胞代谢物、巨噬细胞极化信号和疾病发生之间的联系.
Research progress on multiple metabolites and macrophage polarity regulation
Macrophages are the most important type of innate immune cells,functional diversity and polarization plasticity are two of its important characteristics.Base on the perspective of polarization,macrophages are generally divided into two subgroups:M1 pro-inflammatory cells that kill pathogens and tumor cells,and M2 anti-inflammatory cells that promote tissue repair and angiogenesis.In addition,macrophages can actively adjust their own signals according to physiological changes or disease progression to polarize or reshape them in different directions,thereby tending to form macrophages with different functions and different phenotypes.Metabo-lites are one of the most important basic physiological and pathological activity characteristics and external factors.However,influence of metabolites on the polarity remodeling of macrophages during physiological changes or disease progression remains to be summa-rized.Therefore,as an entry point for exocrine metabolites or intracellular leakage metabolites,this review systematically summarizes the effects of different metabolites on polarization of macrophages and their mechanism of action.Sort out the effects of metabolite changes in pathological microenvironment of various diseases on the polarization of macrophages and their effects on disease progres-sion,aiming to explore the relationship between cell metabolites,macrophage polarization signals and the occurrence of diseases from a multi-factor and multi-dimensional perspective.

MacrophagesPolarity remodelingMetabolitesOrganizational microenvironmentDisease occurrence

宋丹、辛彦龙、庞依心、王梦杰、林语诗、熊晓蕃、耿晶

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西藏民族大学医学院,西藏高原相关疾病分子遗传机制与干预研究省级重点实验室,咸阳 712082

西安交通大学第二附属医院,生物诊断治疗国家地方联合工程研究中心,西安 710004

西安交通大学第二附属医院,细胞应激与疾病诊疗国际联合研究中心,西安 710004

巨噬细胞 极性重塑 代谢物 组织微环境 疾病发生

国家自然科学基金项目国家自然科学基金项目陕西省千人计划青年项目西藏自治区科技厅自然科学基金项目陕西省自然科学基础研究计划项目

3207089132160165YJ0866XZ202201ZR0065G2020JQ-556

2024

10.3969/j.issn.1000-484X.2024.04.030

中国免疫学杂志
中国免疫学会,吉林省医学期刊社

中国免疫学杂志

CSTPCD北大核心
影响因子：0.926
ISSN：1000-484X
年,卷(期)：2024.40(4)
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