真菌毒素对树突状细胞免疫应答的影响
Effects of mycotoxins on immune response of dendritic cells
于欢 1尚国富 1欧沙 1洪亮 1曾柱 1胡祖权1
作者信息
- 1. 贵州医科大学生物与工程学院,贵州省感染免疫与抗体工程特色重点实验室,省部共建药用植物功效与利用国家重点实验室,贵阳 550025
- 折叠
摘要
真菌毒素是病原真菌产生的次级代谢产物,常污染多种农作物,通过食物链对人畜健康造成严重危害.真菌毒素具有多种毒性作用,包括神经毒性、肝毒性、免疫毒性、致畸性和致癌性等,但其免疫毒性机制尚不完全清楚.树突状细胞(DCs)作为功能最强大的抗原提呈细胞,在启动先天免疫和获得性免疫应答中发挥重要作用.现有研究发现真菌毒素能够影响DCs的内吞作用、刺激T细胞活化的能力以及细胞因子和趋化因子的分泌,本文旨在综述真菌毒素对DCs免疫应答的影响,为后续研究阐明真菌毒素的免疫毒性机制提供参考.
Abstract
Mycotoxins are secondary metabolites produced by pathogenic fungi.They often contaminate various crops,and are detrimental to human and animal health.Mycotoxins have a variety of toxic effects,such as neurotoxicity,hepatotoxicity,immunotox-icity,teratogenicity,and carcinogenicity.However,the mechanism of immunotoxicity is still unclear.Dendritic cells(DCs),as the most potent antigen presenting cells,play a vital role in initiating innate and adaptive immune responses.Previous studies have found that mycotoxins can affect the endocytosis of DCs,the ability to stimulate T cell activation,the secretion of cytokines and chemokines.Thus,this review is aim to summarize the effects of mycotoxins on DCs-mediated immune responses,which may provide reference for researches to clarify the immunotoxicity mechanism of mycotoxins.
关键词
真菌毒素/免疫毒性/树突状细胞/抗原提呈细胞Key words
Mycotoxins/Immunotoxicity/Dendritic cells/Antigen-presenting cells引用本文复制引用
基金项目
国家自然科学基金项目(21906036)
贵州省科技计划项目(黔科合基础-ZK[2021]重点029)
贵州省科技计划项目(黔科合支撑[2019]2787号)
贵州省科技计划项目(黔科合平台人才[2016]5676)
出版年
2024
国家科技期刊平台
NSTL
万方数据