Notch信号通路在感染过程中对免疫应答的调控作用
Regulation of Notch signaling pathway in immune responses during infection
麦文豪 1陈楚溪 1刘巧媛 1宁云山 1李妍1
作者信息
- 1. 南方医科大学检验与生物技术学院,广州 510515
- 折叠
摘要
感染启动的先天性和适应性免疫应答依赖于巨噬细胞、树突状细胞以及T细胞等对病原体的识别与控制.Notch信号是一种高度保守的信号通路,通过相邻细胞间配受体结合被激活,进而协调细胞的重要生命过程.目前已证实Notch信号通路参与多种免疫细胞发育、分化、成熟和激活,并在感染性疾病中发挥重要作用.本文综述Notch信号通路在不同病原体感染过程中的免疫调控作用及其与其他通路的相互作用,并讨论在感染性疾病中以Notch信号为靶点的治疗方法及面临的挑战.
Abstract
Innate and adaptive immune responses initiated by infection depend on recognition and control of pathogens by macrophages,dendritic cells,T cells and so on.Notch signaling pathway is a highly conserved pathway,which is activated by interac-tion of receptors and ligands,thus coordinating important life processes of cells.At present,it has been confirmed that Notch signaling pathway is involved in development,differentiation,maturation and activation of many kinds of immune cells,and plays an important role in infectious diseases.In this review,we mainly focus on the role of Notch signaling pathway in immune regulation during different pathogens infection and its interaction with other signaling pathways.Additionally,therapeutic methods and challenges of developing Notch signaling as a target in infectious diseases are also discussed.
关键词
Notch信号通路/感染/免疫应答/巨噬细胞/树突状细胞/T细胞Key words
Notch signaling pathway/Infection/Immune response/Macrophages/Dendritic cells/T cells引用本文复制引用
基金项目
国家自然科学基金面上项目(81971903)
广东省自然科学基金(2023A1515010084)
广东省大学生创新训练项目(S202212121162)
广东省大学生创新训练项目(S202312121157)
出版年
2024
国家科技期刊平台
NSTL
万方数据