B-cell-specific moloney murine leukemia virus integration site 1(BMI1)molecule is one of the members of the family of the Polycomb group(PcG)protein.As a crucial marker of stem cells,it maintains the normal physiological functions of the or-ganisms through regulating expression of the related genes transcriptionally.It was reported that BMI1 is also a crucial molecule which affects pathogenesis and progression of malignant tumors.Therefore,it plays an important role in regulating self-renewal,migration,invasion,drug-resistance,and as well as immune evasion of cancer stem cells(CSCs),which is associated with recurrence and metas-tasis of cancer.In this review,based on the research progresses during recent years,molecular structure and biological function of BMI1 were illustrated.Furthermore,regulation and its mechanisms of BMI1 molecule on the self-renewal,migration and invasion,drug-resistance and immune evasion of CSCs were also elaborated.It indicated that investigation of BMI1 molecule as a novel potential target in cancer immunotherapy would be much valuable and significant.
关键词
BMI1/肿瘤干细胞/自我更新/迁移侵袭/耐药/免疫逃逸
Key words
BMI1/Cancer stem cells/Self-renewal/Migration and invasion/Drug-resistance/Immune evasion
维普
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