基于Th17/Treg平衡探讨骨质疏松症研究进展
Research progress of osteoporosis based on Th17/Treg balance
王嘉玉 1颜春鲁 1安方玉 1袁灵青 1王霞霞1
作者信息
摘要
骨质疏松症(OP)是一种慢性全身代谢性骨病,近年随着人口老龄化发展其发病率不断升高,给家庭和社会带来了巨大经济负担.造成OP的原因有很多,如衰老、氧化应激、表观遗传等,随着研究的深入,炎症因子等骨免疫学进入人们的视野.Th17细胞是一种效应性T细胞亚群,可诱导炎症发展,促进骨丢失.相反,Treg可维持自身耐受,进而抑制自身免疫,起骨保护作用.生理条件下,Th17/Treg平衡可维持骨稳态,而病理条件下,Th17/Treg失衡可导致骨丢失.基于此,本文对OP中介导Th17/Treg平衡的通路和细胞因子等进行综述,以期为OP治疗提供新的思路和方法.
Abstract
Osteoporosis(OP)is a chronic systemic metabolic bone disease.In recent years,with development of population aging,incidence of OP is also increasing,bringing huge economic burden to family and society.There are many causes of OP,such as aging,oxidative stress,epigenetic and many other aspects,and with further development of research,inflammatory factors and other bone immunology into people's vision.Th17 cells are effector T cell subpopulation that induce development of inflammation and promote bone loss.On the contrary,Treg can maintain their own tolerance and further suppress their own immunity,thus playing a bone protective role.Under physiological conditions,Th17/Treg balance can maintain bone homeostasis,while under pathological condi-tions,disruption of Th17/Treg balance can lead to bone loss.Based on this,this paper will review pathways and cytokines mediating Th17/Treg balance in OP,in order to provide new ideas and methods for treatment of OP.
关键词
骨质疏松症/骨免疫学/Th17细胞/TregKey words
Osteoporosis/Bone immunology/Th17 cells/Treg引用本文复制引用
基金项目
国家自然科学基金(82060872)
甘肃省中医药科研课题(GZKP-2023-39)
甘肃省中医药科研课题(GZKP-2023-63)
甘肃中医药大学研究生教育教学研究与改革项目(2023-15)
出版年
2024
国家科技期刊平台
NSTL
万方数据