Research progress of TCR DNA vaccine in autoimmune diseases
Autoimmune disease(AID)is a disease in which the body loses tolerance to autoantigens and the immune system attacks its own tissues,resulting in organ and tissue damage and certain clinical manifestations.Studies have proved that pathogenic T cells can be selectively inhibited or killed by TCR vaccine in the treatment of AID,thus bringing broad application prospect.This pa-per briefly summarizes the research status of TCR vaccine in AID field,regarding action mechanism,related diseases and safety of TCR vaccine.