免疫细胞疗法在IBD治疗中的研究进展
Progress of immunocellular therapy in treatment of IBD
周建伟 1张哲 1刘霞 1孙亚星 1王亮 1冯百岁1
作者信息
- 1. 郑州大学第二附属医院消化内科,郑州 450014
- 折叠
摘要
炎症性肠病(IBD)是一种以慢性、复发性肠道炎症为特征的疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC).其病因和发病机制仍然不明,难以治愈.近年来,以调节性T(Treg)细胞疗法和树突状细胞(DC)疗法为代表的免疫细胞疗法在免疫相关疾病治疗领域发展十分迅速,在IBD治疗领域也取得了一定进展.本文主要介绍Treg细胞疗法和DC疗法在IBD治疗中的应用及进展.
Abstract
Inflammatory bowel disease(IBD)is a disease characterized by chronic,recurrent intestinal inflammation,includ-ing Crohn's disease(CD)and ulcerative colitis(UC).Etiology and pathogenesis of IBD are unknown,and the treatment is difficult.In recent years,immunocellular therapy represented by regulatory T(Treg)cell therapy and dendritic cell(DC)therapy has developed rapidly in the field of immune-related disease treatment,and some progress has also been made in the treatment of IBD.This review will introduce application and progression of Treg cell therapy and DC therapy in IBD treatment.
关键词
炎症性肠病/免疫细胞疗法/调节性T细胞/树突状细胞Key words
Inflammatory bowel disease/Immunocellular therapy/Regulatory T cell/Dendritic cell引用本文复制引用
基金项目
河南省重点研发与推广专项(科技攻关)(212102310803)
河南省医学科技攻关计划联合共建项目(2021)(LHGJ20210409)
河南省医学科技攻关计划联合共建项目(2021)(LHGJ20210424)
河南省医学科技攻关计划联合共建项目(2021)(LHGJ20210416)
出版年
2024
国家科技期刊平台
NSTL
万方数据