NK细胞的发育分化及转录因子调控
Development and transcriptional regulation of NK cells
何悦颜 1彭慧1
作者信息
- 1. 中国科学技术大学生命科学与医学部,前沿交叉科学与生物医学研究所,合肥 230027
- 折叠
摘要
自然杀伤(NK)细胞是固有免疫系统重要成员,在抗病毒以及抗肿瘤中发挥重要作用.NK细胞发育分化历经多个阶段,受多种因素调控.成年机体外周组织广泛存在的经典NK(cNK)细胞主要由骨髓造血干细胞(HSCs)经共同淋巴祖细胞(CLPs)、NK细胞前体(NKPs)阶段发育而来,转录因子在调控造血前体向NK细胞分化过程中发挥关键作用.近年随着固有淋巴细胞(ILCs)家族其他成员的发现和深入研究,揭示了NK细胞具有独立于其他ILCs亚群的发育路径,NK细胞发育分化阶段界定更为精细,一系列调控NK细胞各阶段发育分化的转录因子也逐步被发现.本文围绕NK细胞发育阶段的界定和转录因子调控方面展开论述,将有助于深入理解NK细胞的发育分化过程.
Abstract
Natural killer(NK)cells are important members of innate immune system,playing an important role in anti-viral and anti-tumor responses.Development and differentiation of NK cells go through multiple stages and are regulated by a variety of factors.Conventional NK(cNK)cells,which are widely present in peripheral tissues of adult organisms,mainly develop from bone marrow hematopoietic stem cells(HSCs)through common lymphoid progenitors(CLPs)and NK cell precursors(NKPs).Transcrip-tion factors play a key role in regulating differentiation of hematopoietic precursors into NK cells.In recent years,with discovery and in-depth study of other members of innate lymphoid cells(ILCs)family,it has been revealed that NK cells have a developmental path-way independent of other ILC subsets,development and differentiation stages of NK cells have been more finely defined,and a series of transcription factors regulating development and differentiation of NK cells at various stages have been gradually discovered.This article focuses on definition of NK cell development stages and regulation of transcription factors,which will improve our understanding of development and differentiation of NK cells.
关键词
NK细胞/发育分化/转录调控Key words
NK cells/Development and differentiation/Transcriptional regulation引用本文复制引用
基金项目
合肥综合性国家科学中心大健康研究院前沿交叉科学与生物医学研究所资助项目(QYZD20220005)
出版年
2024
国家科技期刊平台
NSTL
万方数据