Development and transcriptional regulation of NK cells
Natural killer(NK)cells are important members of innate immune system,playing an important role in anti-viral and anti-tumor responses.Development and differentiation of NK cells go through multiple stages and are regulated by a variety of factors.Conventional NK(cNK)cells,which are widely present in peripheral tissues of adult organisms,mainly develop from bone marrow hematopoietic stem cells(HSCs)through common lymphoid progenitors(CLPs)and NK cell precursors(NKPs).Transcrip-tion factors play a key role in regulating differentiation of hematopoietic precursors into NK cells.In recent years,with discovery and in-depth study of other members of innate lymphoid cells(ILCs)family,it has been revealed that NK cells have a developmental path-way independent of other ILC subsets,development and differentiation stages of NK cells have been more finely defined,and a series of transcription factors regulating development and differentiation of NK cells at various stages have been gradually discovered.This article focuses on definition of NK cell development stages and regulation of transcription factors,which will improve our understanding of development and differentiation of NK cells.
NK cellsDevelopment and differentiationTranscriptional regulation
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