Effects of pulmonary fever and cough oral liquid combined with chlor-pheniramine on symptoms,pro/anti-inflammatory balance and prognosis in children with chronic cough
Objective:To investigate the effects of pulmonary fever and cough oral liquid combined with chlorpheniramine on symptoms,pro/anti-inflammatory balance and prognosis in children with chronic cough.Methods:A total of 150 children with chronic cough in Luohe Central Hospital from June 2017 to December 2019 were selected,and randomly divided into 3 groups,with 50 cases in each group.All 3 groups were treated with conventional treatment,pulmonary fever and cough oral solution+chlorpheniramine in group A,pulmonary fever and cough oral solution in group B,and chlorpheniramine in group C,all treated for 10 days.Clinical efficacy,adverse effects,prognosis and pre-and post-treatment symptom scores,respiratory physiological indexes[maximum mid-expiratory flow rate(MMEF75/25),1st second forceful expiratory volume as a percentage of expected value(FEV1%),maximum peak expiratory flow rate(PEF)],pro/anti-inflammatory factors(IL-5,IL-13,IFN-γ,IL-10)were observed in three groups.Results:①Total treat-ment efficiency and PEF,MMEF75/25,FEV1%in group A were higher than those in groups B and C,while symptom scores were lower than those in groups B and C(P<0.05),there was no statistically significant difference between the total treatment efficiency,symp-tom scores and respiratory physiological indexes in groups B and C(P>0.05);②After treatment,levels of IL-5 and IL-13 in group A were lower than those in groups B and C,while levels of IFN-γ and IL-10 were higher than those in groups B and C.Moreover,levels of IL-5 and IL-13 in group B were lower than those in group C,while levels of IFN-γ and IL-10 were higher than those in group C(P<0.05);③There was no statistically significant difference in the incidence of adverse reactions and recurrence rate between the three groups(P>0.05).Conclusion:Pulmonary fever and cough oral liquid combined with chlorpheniramine is effective in treating chronic cough,which is beneficial in relieving cough symptoms and improving respiratory function,and the mechanism may be related to cor-recting the pro-inflammatory/anti-inflammatory imbalance.
Chronic coughChlorpheniraminePulmonary fever and cough oral solutionPro-inflammatory/anti-inflammatory balancePrognosis
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