TOX介导T细胞耗竭的机制及其逆转研究
Advances in mechanism and reversal of TOX-mediated T cell exhaustion
黄舒欣 1李扬秋 1陈少华1
作者信息
- 1. 暨南大学基础医学与公共卫生学院血液学研究所,广州 510632
- 折叠
摘要
胸腺细胞选择相关的高迁移率族蛋白(TOX)是一种与DNA结合的转录因子,参与免疫细胞的发育过程.TOX是促进T细胞耗竭的关键转录因子,并与肿瘤的发生发展密切相关,提示TOX可能是潜在的免疫生物标志物和恶性肿瘤免疫治疗的靶点.本文就TOX介导T细胞耗竭的分子机制及其逆转研究的最新进展做一综述,为设计基于TOX更为精准的肿瘤免疫治疗策略提供依据.
Abstract
Thymocyte selection-associated HMG box(TOX)is a DNA-binding transcription factor that involved in the deve-lopment of immune cells.Several studies have shown that TOX is a critical regulator of T cell exhaustion,and associated with the de-velopment of tumorigenesis,suggesting that TOX may be a potential immune biomarker and target for immunotherapy for malignant tu-mors.In this review,we review the molecular mechanisms and reversals of TOX mediated T cell depletion and provide evidence for the design of more accurate tumor immunotherapy strategies based on TOX.
关键词
TOX/T细胞耗竭/肿瘤免疫治疗Key words
TOX/T cell exhaustion/Tumor immunotherapy引用本文复制引用
基金项目
国家自然科学基金(81570143)
国家自然科学基金(82070152)
国家自然科学基金(82293632)
出版年
2024
国家科技期刊平台
NSTL
万方数据