Advances in mechanism and reversal of TOX-mediated T cell exhaustion
Thymocyte selection-associated HMG box(TOX)is a DNA-binding transcription factor that involved in the deve-lopment of immune cells.Several studies have shown that TOX is a critical regulator of T cell exhaustion,and associated with the de-velopment of tumorigenesis,suggesting that TOX may be a potential immune biomarker and target for immunotherapy for malignant tu-mors.In this review,we review the molecular mechanisms and reversals of TOX mediated T cell depletion and provide evidence for the design of more accurate tumor immunotherapy strategies based on TOX.
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