变应性鼻炎最轻持续性炎症的研究进展
Advances of studies on minimal persistent inflammation of allergic rhinitis
陈祥静 1张立峰 1孟伟 1王仁忠1
作者信息
- 1. 山东中医药大学附属医院耳鼻喉科,济南 250014
- 折叠
摘要
变应性鼻炎(AR)最轻持续性炎症(MPI)是AR患者接触低剂量变应原诱发的鼻腔黏膜局部的无症状炎症.随着对这一状态研究的深入,研究者们逐渐意识到这种局部的亚临床炎症不仅对鼻腔黏膜有着慢性损伤,而且增加了变应性气道疾病的高敏性和高反应性.MPI概念的提出改变了AR的治疗策略,这要求我们不仅要干预AR的发作期,还要干预MPI期.本文对AR MPI发生的免疫学机制、不良影响及治疗策略进行了系统综述,为更好地治疗AR MPI,降低AR的复发提供证据支持.
Abstract
The minimal persistent inflammation(MPI)of allergic rhinitis(AR)is asymptomatic inflammation that occurs locally in the nasal mucosa after exposure to low doses of allergens.With the study of MPI,researchers have realized that this local sub-clinical inflammation in patients with AR not only causes chronic damage to the nasal mucosa,but also increases the hypersensitivity and hyperresponsiveness of allergic airway disease.The concept of MPI has changed our strategy for the treatment of AR,which re-quires that we should not only intervene in the symptomatic exacerbation period,but also intervene in the asymptomatic MPI period.This article systematically reviews the immunological mechanism,adverse effects,and treatment strategies of the MPI,to provide bet-ter treatment for the MPI of AR and reduce the recurrence of AR.
关键词
变应性鼻炎/最轻持续性炎症/免疫机制/治疗/综述Key words
Allergic rhinitis/Minimal persistent inflammation/Immune mechanism/Treatment/Review引用本文复制引用
基金项目
国家自然科学基金项目(81974580)
国家自然科学基金项目(82305327)
出版年
2024
国家科技期刊平台
NSTL
万方数据