CD4+CD28-T细胞的特点及其在疾病中的作用研究进展
Progress in research on characteristics of CD4+CD28-T cells and their roles in diseases
林倩 1王子龙 2王冠 2刘畅1
作者信息
- 1. 大连理工大学附属中心医院风湿免疫科,大连 116033
- 2. 大连医科大学基础医学院免疫学教研室,大连 116044
- 折叠
摘要
在健康的年轻人体内,传统CD4+T细胞的CD28表达高达97.5%,而研究发现在老年人、慢性炎症和持续感染的患者体内CD4+T细胞的CD28阳性率显著下降,甚至不足50%,即出现CD4+CD28-T细胞积累.CD4+CD28-T细胞是一群独特的CD4+T细胞亚群,本文综述了该亚群的表型特征、功能特点及其在慢性病毒感染、自身免疫病和心血管疾病中的作用,为CD4+CD28-T细胞相关疾病的治疗和预后改善提供了新策略.
Abstract
In healthy young people,the expression of CD28 in regular CD4+T cells is 97.5%.However,studies have shown that in the elderly and patients with chronic inflammation and persistent infection,the positiveness of CD28 in CD4+T cells decrease significantly,even less than 50%,that is,the accumulation of CD4+CD28-T cells.CD4+CD28-T cells are a unique subset of CD4+T cells.In this review,we describes the characteristics of phenotype and function and their roles in chronic viral infections,autoimmune diseases,cardiovascular diseases of CD4+CD28-T cells,providing new strategies for the treatment and prognosis improvement of CD4+CD28-T cell-related diseases.
关键词
CD4+CD28-T细胞/炎症反应/细胞毒性Key words
CD4+CD28-T cells/Inflammatory response/Cytotoxicity引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据