PD-1/PD-L1信号通路在脓毒症不同器官免疫调控中的研究进展
Research progress of PD-1/PD-L1 signaling pathway in immune regulation of different organs in sepsis
张登容 1刘春瑶 1卜婷婷 1罗镇颉 1龙仙萍 2汪松1
作者信息
- 1. 遵义医科大学附属医院急诊科,遵义 563000
- 2. 遵义医科大学附属医院心内科,遵义 563000
- 折叠
摘要
脓毒症是宿主对感染的免疫反应失调引起的威胁生命的器官功能障碍,其免疫调控机制复杂,目前尚未阐明.程序性死亡受体-1(PD-1)/程序性死亡受体配体-1(PD-L1)是近年来备受关注的负性共抑制分子.研究表明,PD-1/PD-L1信号通路在脓毒症中发挥重要免疫抑制作用,在心、肝、脾、肺、肾中的免疫调控机制存在差异,尚未完全阐明.本文就PD-1/PD-L1在脓毒症不同器官中的免疫调控作用进行综述,以期为脓毒症的研究提供新的方向.
Abstract
Sepsis is a life-threatening organ dysfunction caused by the imbalance of host immune response to infection,which immune regulation mechanism is complex and has not been clarified.Programmed death receptor-1(PD-1)/programmed death recep-tor ligand-1(PD-L1)is a negative co-inhibitory molecule that has attracted much attention in recent years.Studies have shown that PD-1/PD-L1 signaling pathway plays an important immunosuppressive role in sepsis.There are differences in immune regulation mecha-nisms in heart,liver,spleen,lung and kidney,which has not been clarified.Immune regulation of PD-1/PD-L1 in different organs of sepsis is reviewied in this article,which could to provide a new direction for the study of sepsis.
关键词
脓毒症/PD-1/PD-L1/免疫调控Key words
Sepsis/PD-1/PD-L1/Immunoregulation引用本文复制引用
基金项目
国家自然科学基金(8216020197)
贵州省科技厅联合基金(黔科合LH字[2017]7094号)
出版年
2024
国家科技期刊平台
NSTL
万方数据