P2RX7对组织驻留淋巴细胞的作用
Role of P2RX7 in tissue-resident lymphocytes
赵悦琳 1宋浩1
作者信息
- 1. 中国科学技术大学免疫学研究所,合肥 230027
- 折叠
摘要
组织驻留淋巴细胞在炎症和癌症等疾病中发挥重要作用,为机体稳态的维持建立起第一道防线.当机体出现炎症、病毒感染或癌变时,组织驻留淋巴细胞会迅速响应并及时应答.然而,组织驻留淋巴细胞功能也会受到局部微环境的调控,受损组织中会积累大量ATP,继而激活免疫细胞上的P2X嘌呤能受体,调控免疫细胞应答并影响疾病发展.目前认为在P2X嘌呤能受体家族中,P2RX7在免疫系统中发挥了最广泛的作用,表达在几乎所有免疫细胞上,而组织驻留淋巴细胞上P2RX7的表达水平较高.多种肿瘤模型证实靶向P2RX7治疗是非常有效的癌症治疗策略,但其与组织驻留淋巴细胞的关系尚不清晰.本综述主要介绍P2RX7对不同组织驻留淋巴细胞稳态维持和效应功能的影响,以及如何进一步影响组织炎症、病毒感染或癌症等疾病的发生发展.
Abstract
Tissue-resident lymphocytes constitute the first line of defense against diseases and are important for maintaining body homeostasis.During inflammation,virus infection and carcinogenesis,tissue-resident lymphocytes will immediately response and exert effector functions.However,these processes are regulated by multiple factors in the local microenvironment such as ATP,which accumulates in damaged tissues,and regulates disease progression via activating P2X purinergic receptors on immune cells.Among the P2X purinergic receptor family,P2RX7 is well studied and participates in broad immune responses.P2RX7 is expressed on nearly all immune cells,with particularly high levels of expression on tissue-resident lymphocytes.Multiple tumor models have con-firmed that targeting R2RX7 is a very promising therapeutic strategy in the treatment of cancer but its relationship with tissue-resident lymphocytes is unclear.In this review,we mainly discuss the effects of P2RX7 on tissue-resident lymphocyte populations and how it further affects the development of diseases such as inflammation,virus infection or cancer development.
关键词
组织驻留淋巴细胞/ATP/P2RX7/疾病Key words
Tissue-resident lymphocytes/ATP/P2RX7/Diseases引用本文复制引用
基金项目
国家自然科学基金青年科学基金(32200737)
出版年
2024
国家科技期刊平台
NSTL
万方数据