Tissue-resident lymphocytes constitute the first line of defense against diseases and are important for maintaining body homeostasis.During inflammation,virus infection and carcinogenesis,tissue-resident lymphocytes will immediately response and exert effector functions.However,these processes are regulated by multiple factors in the local microenvironment such as ATP,which accumulates in damaged tissues,and regulates disease progression via activating P2X purinergic receptors on immune cells.Among the P2X purinergic receptor family,P2RX7 is well studied and participates in broad immune responses.P2RX7 is expressed on nearly all immune cells,with particularly high levels of expression on tissue-resident lymphocytes.Multiple tumor models have con-firmed that targeting R2RX7 is a very promising therapeutic strategy in the treatment of cancer but its relationship with tissue-resident lymphocytes is unclear.In this review,we mainly discuss the effects of P2RX7 on tissue-resident lymphocyte populations and how it further affects the development of diseases such as inflammation,virus infection or cancer development.
国家科技期刊平台
NSTL
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