经典Wnt/β-catenin信号在过敏性哮喘中的功能研究进展
Advances in researches of classical Wnt/β-catenin signal function in allergic asthma
刘胜男 1王文静 1张欢欢 1伊淑莹1
作者信息
- 1. 山东第一医科大学临床与基础医学院,济南 250062
- 折叠
摘要
过敏性哮喘是一种复杂的呼吸系统异质性疾病,在遗传水平上具有广泛的变异性,并有多种机会改变遗传多样性.越来越多的研究表明,靶向Wnt/β-catenin信号途径可以影响过敏性哮喘的发生发展,但其具体免疫性作用机制尚不明确.本文主要通过介绍Wnt/β-catenin信号及其在过敏性哮喘中的作用和功能,为治疗过敏性哮喘的药物干预提供新靶点.
Abstract
Allergic asthma is a complex heterogeneous disease of respiratory system.It has extensive variability at the genetic level,and has a variety of opportunities to change genetic diversity.More and more studies have shown that targeting Wnt/β-catenin signaling pathway can affect the occurrence and development of allergic asthma,but its specific immune mechanism is not clear.In this paper,we mainly introduce Wnt/β-catenin signal and its role and function in allergic asthma provide a new target for drug inter-vention in the treatment of allergic asthma.
关键词
过敏性哮喘/Wnt/β-catenin信号/免疫/药物干预Key words
Allergic asthma/Wnt/β-catenin signaling/Immunity/Drug intervention引用本文复制引用
基金项目
国家自然科学基金项目(81971512)
山东省医药卫生科技发展计划项目(2018WS136)
山东省高等学校青年创新人才引育计划项目(rcjf005)
出版年
2024