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肠-关节轴:肠黏膜免疫与类风湿关节炎的关系探讨

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类风湿关节炎(RA)是一类病因未明的慢性、以炎性滑膜炎为主的自身免疫性疾病,其发生、发展与肠黏膜免疫密切相关.肠道菌群失调、肠屏障完整性受损、肠黏膜局部自身抗体的产生以及肠固有层免疫细胞的变化等因素均可成为RA致病的潜在风险.本文详细探讨了肠道黏膜免疫与RA之间的关系(肠-关节轴),以期为RA的治疗提供新的思路和理论依据.
Gut-joint axis:Relationship between intestinal mucosal immunity and rheumatoid arthritis
Rheumatoid arthritis(RA)is a type of chronic autoimmune disease with unknown etiology and inflammatory syno-vitis.The occurrence and development of RA are closely related to intestinal mucosal immunity.Imbalance of intestinal flora,impaired intestinal barrier integrity,production of local autoantibodies and changes of immune cells in the lamina propria are all potential risks of RA.We explored the relationship between intestinal mucosal immunity and RA(gut-joint axis)in detail,with respect to provide novel thought and theoretical basis for the treatment of RA.

Intestinal mucosal immunityRheumatoid arthritisImmune cellsGut microbiota

冀鹏、沙舟、张薇、史丽云

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南京中医药大学医学院·整合医学学院,南京 210023

肠黏膜免疫 类风湿关节炎 免疫细胞 肠道菌群

国家自然科学基金国家自然科学基金

8237181282000014

2024

中国免疫学杂志
中国免疫学会,吉林省医学期刊社

中国免疫学杂志

CSTPCD北大核心
影响因子:0.926
ISSN:1000-484X
年,卷(期):2024.40(9)