肠-关节轴:肠黏膜免疫与类风湿关节炎的关系探讨
Gut-joint axis:Relationship between intestinal mucosal immunity and rheumatoid arthritis
冀鹏 1沙舟 1张薇 1史丽云1
作者信息
- 1. 南京中医药大学医学院·整合医学学院,南京 210023
- 折叠
摘要
类风湿关节炎(RA)是一类病因未明的慢性、以炎性滑膜炎为主的自身免疫性疾病,其发生、发展与肠黏膜免疫密切相关.肠道菌群失调、肠屏障完整性受损、肠黏膜局部自身抗体的产生以及肠固有层免疫细胞的变化等因素均可成为RA致病的潜在风险.本文详细探讨了肠道黏膜免疫与RA之间的关系(肠-关节轴),以期为RA的治疗提供新的思路和理论依据.
Abstract
Rheumatoid arthritis(RA)is a type of chronic autoimmune disease with unknown etiology and inflammatory syno-vitis.The occurrence and development of RA are closely related to intestinal mucosal immunity.Imbalance of intestinal flora,impaired intestinal barrier integrity,production of local autoantibodies and changes of immune cells in the lamina propria are all potential risks of RA.We explored the relationship between intestinal mucosal immunity and RA(gut-joint axis)in detail,with respect to provide novel thought and theoretical basis for the treatment of RA.
关键词
肠黏膜免疫/类风湿关节炎/免疫细胞/肠道菌群Key words
Intestinal mucosal immunity/Rheumatoid arthritis/Immune cells/Gut microbiota引用本文复制引用
基金项目
国家自然科学基金(82371812)
国家自然科学基金(82000014)
出版年
2024
国家科技期刊平台
NSTL
万方数据