摘要
肿瘤干细胞(CSCs)是在肿瘤中发现的与正常干细胞一样具有自我更新特性的细胞.近年随着科学研究的不断发展,人们对肿瘤的研究不断加深,CSCs已被定义为促进肿瘤发展的关键因素,参与推动肿瘤复发、转移、化疗、耐药性等.CD133已成为热门的CSCs标志物之一,可在多种CSCs中高表达,且与肿瘤诊断的联系密不可分,可在胃癌、肺癌、脑肿瘤、肝癌、卵巢癌以及结直肠癌中发挥重要诊断及药物研究靶点作用.本文主要介绍CD133的结构、功能、免疫机制逃逸及其介导的肿瘤信号通路,并总结其与各类肿瘤的相关性.
Abstract
Cancer stem cells(CSCs)are a small group of cells found in tumors that have same self-renewing properties as nor-mal stem cells.In recent years,with continuous development of science and technology in various aspects,people's research on tumor diseases has been deepened.CSCs has been defined as a key factor in promoting tumor development,especially participating in pro-moting tumor recurrence,metastasis,chemotherapy resistance,etc.Currently,CD133 has become one of popular CSCs markers,and can be highly expressed in a variety of CSCs.CD133 is closely related to diagnosis of cancer diseases,and plays an important role in dignosis and drug targeting for gastric cancer,lung cancer,brain tumor,liver cancer,ovarian cancer and colorectal cancer.This article reviews structure,function,immune mechanism escape of CD133,signal pathway of CD133 in tumorigenesis,and correlation of CD133 with various tumors as well.
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