mTOR调控T细胞增殖与功能的研究进展
Research progress of mTOR regulating T cell proliferation and function
吴涵 1黄红 1易欧阳 1胡明月 1刘良 2蔡雄1
作者信息
- 1. 湖南中医药大学科技创新中心,长沙 410208
- 2. 广州中医药大学中医证候全国重点实验室,广州 510000
- 折叠
摘要
雷帕霉素机制性靶蛋白(mTOR)在细胞生长、增殖、分化等多个方面起关键作用.T淋巴细胞是人体免疫系统的重要组成,本文总结了mTOR如何通过糖代谢和脂质代谢等代谢途径来调控T细胞功能,并探讨了mTOR在T细胞分化中的关键性作用.此外,本文还归纳了近年来天然化合物通过作用于mTOR来调控T细胞的研究进展,这些发现有望为未来以mTOR为靶点的疾病治疗提供新的思路和方法.
Abstract
The mechanistic target of rapamycin(mTOR)plays a pivotal role in various cellular processes,including growth,proliferation and differentiation.As an essential component of the human immune system,T lymphocytes are regulated by mTOR through metabolic pathways such as carbohydrate metabolism and lipid metabolism.This article summarizes the critical role of mTOR in T cell differentiation and reviews recent advances in natural compounds that modulate T cells via mTOR.These findings contribute to the development of mTOR-targeted therapies for diseases.
关键词
mTOR/T淋巴细胞/糖代谢/脂质代谢/天然化合物Key words
mTOR/T lymphocytes/Carbohydrate metabolism/Lipid metabolism/Natural compounds引用本文复制引用
基金项目
国家自然科学基金项目(82274506)
湖南省科技创新计划(2021RC4035)
出版年
2024
国家科技期刊平台
NSTL
万方数据