内质网应激在免疫细胞中的作用研究进展
Research progress of endoplasmic reticulum stress in immune cells
卢桃 1张茵 1李川 1林世德1
作者信息
- 1. 遵义医科大学附属医院感染科,遵义 563000
- 折叠
摘要
免疫应答发生在各种细胞应激中,严重扰乱内质网(ER)功能,导致错误折叠或未折叠蛋白在ER管腔积聚,从而引起内质网应激(ERS).ERS触发未折叠蛋白反应以恢复ER稳态,但持续时间过长,可导致细胞凋亡.虽然持续的ERS可导致促炎细胞因子增加从而诱导炎症反应,激活免疫应答,但ERS与免疫应答间的因果关系尚无定论.本文综述了ERS在诱导免疫细胞分化、细胞因子表达、免疫功能中的作用,进一步阐述免疫细胞ERS在免疫紊乱发病机制中的调控作用,有助于挖掘针对ERS相关疾病的新疗法.
Abstract
Immune response occurs in a variety of cellular stresses that severely disrupt function of endoplasmic reticulum(ER),leading to accumulation of misfolded or unfolded protein in ER lumen,resulting in endoplasmic reticulum stress(ERS).ERS triggers unfolded protein response to restore ER homeostasis,but its duration is too long and can lead to cell apoptosis.Although sus-tained ERS can lead to an increase in pro-inflammatory cytokines that induce inflammatory responses and activate immune responses,causal relationship between ERS and immune responses has not been established.This review summarizes role of ERS in inducing im-mune cell differentiation,cytokine expression and immune function,and further illustrates regulatory role of ERS in pathogenesis of immune disorders,which is helpful to explore new therapies for ERS-related diseases.
关键词
内质网应激/免疫细胞/免疫紊乱/新疗法Key words
Endoplasmic reticulum stress/Immune cells/Immune disorders/New therapies引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据