间充质干细胞在复发性自然流产中治疗潜能的研究进展
Research progress on therapeutic potential of mesenchymal stem cells in recurrent spontaneous abortion
王清仪 1刘晓芳 1冯晓玲2
作者信息
- 1. 黑龙江中医药大学,哈尔滨 150040
- 2. 黑龙江中医药大学附属第一医院,哈尔滨 150040
- 折叠
摘要
复发性自然流产(RSA)是妊娠早期最常见的并发症之一,影响2%～5%的育龄期女性,其发病率呈逐年上升趋势,不仅对女性的身心健康造成了影响,也给社会和家庭造成沉重的经济负担.间充质干细胞(MSCs)是一类源于多种组织的中胚层间充质的非造血成体多能干细胞,具有多向分化和自我更新等特性,对于RSA患者的生育结局具有改善作用,已成为近年研究的热点.因此,本文探明了不同来源的MSCs改善RSA患者妊娠结局的作用与机制,并分析其研究现状及存在的问题.
Abstract
Recurrent spontaneous abortion(RSA)is one of the most common complications in early pregnancy,affecting about 2%～5%of women of childbearing age,and its incidence is increasing year by year,which not only affects women's physical and mental health,but also causes a heavy economic burden to the society and the family.Mesenchymal stem cells(MSCs)are a class of non-hematopoietic adult multipotent stem cells derived from mesodermal mesenchymal cells of a variety of tissues.They have the characteristics of multi-directional differentiation and self-renewal,and can improve the fertility outcome of RSA patients,which has become a research hotspot in recent years.Therefore,this paper explores the roles and mechanisms of MSCs from different sources in improving pregnancy outcomes in RSA patients,and analyzes their research status and existing problems.
关键词
间充质干细胞/复发性自然流产/干细胞治疗Key words
Mesenchymal stem cells/Recurrent spontaneous abortion/Stem cell therapy引用本文复制引用
基金项目
国家自然科学基金面上项目(81973894)
国家自然科学基金面上项目(82174421)
出版年
2024
国家科技期刊平台
NSTL
万方数据