细胞自噬在胰腺炎症及纤维化中的研究进展
Research progress of autophagy in pancreatic inflammation and fibrosis
高合 1许小凡 1段丽芳 1张红2
作者信息
- 1. 陕西中医药大学,咸阳 712046
- 2. 陕西中医药大学,咸阳 712046;陕西省免疫炎症相关疾病中医药防治国际联合研究中心,咸阳 712046
- 折叠
摘要
慢性胰腺炎(CP)是一种进行性胰腺纤维炎症性疾病,其病理特征表现为胰腺腺泡细胞破坏、炎症细胞浸润、胰腺星状细胞(PSC)活化和胰腺纤维化.细胞自噬是参与细胞稳态维持的重要事件,近来研究显示细胞自噬与CP的发生发展密切相关,而胰腺微环境中的几种细胞自噬在CP进展中发挥着不同的作用,腺泡细胞自噬具有"双刃剑"的效应,PSC自噬与其活化呈正相关,而炎症细胞自噬的作用尚不清楚.本文聚焦于CP微环境中的几种关键细胞,探讨各种细胞自噬在CP进展中的作用和机制.
Abstract
Chronic pancreatitis(CP)is a progressive fibroinflammatory disease characterized by destruction of pancreatic aci-nar cells,infiltration of inflammatory cells,activation of pancreatic stellate cell(PSC),and pancreatic fibrosis.Autophagy partici-pates in the maintenance of cell homeostasis.Recent studies have shown that autophagy closely related to the occurrence and develop-ment of CP.However,several autophagy types in the pancreatic microenvironment play different roles in the progression of CP.The autophagy of acinar cells has a"double-edged sword"effect.PSC autophagy is positively correlated with its activation,while the role of autophagy of inflammatory cells is still unclear.This study focused on some key cells in the CP microenvironment and explored the role and mechanism of autophagy in the progression of CP.
关键词
慢性胰腺炎/胰腺纤维化/自噬/腺泡细胞/胰腺星状细胞/巨噬细胞Key words
Chronic pancreatitis/Pancreatic fibrosis/Autophagy/Acinar cells/Pancreatic stellate cell/Macrophage引用本文复制引用
基金项目
国家自然科学基金(82174201)
国家自然科学基金(82104815)
陕西中医药大学创新团队项目(2019-YL14)
陕西省特支计划(303/141020047)
出版年
2024
国家科技期刊平台
NSTL
万方数据