牛病毒性腹泻病毒疫苗研究进展
Advances on Vaccines of Bovine Viral Diarrhea Virus
张蕾 1陈亮 1韩永胜 1冯万宇 1苗艳 1兰世捷 1沈思思 1李红宇1
作者信息
- 1. 黑龙江省农业科学院畜牧兽医分院,齐齐哈尔 161000
- 折叠
摘要
牛病毒性腹泻病毒(BVDV)由BVDV-1、BVDV-2和BVDV-3三个亚种组成,是给养牛业造成巨大损失的重要病毒性病原体.接种BVDV疫苗是预防牛病毒性腹泻的主要策略之一.BVDV的结构蛋白E2和Erns是诱导中和抗体产生和激发保护性免疫应答的主要抗原蛋白,也是疫苗研究中常用的靶点蛋白.文章对BVDV的病原结构、宿主免疫应答以及目前BVDV经典疫苗和新型重组疫苗的最新研究进展进行了综述,以期为BVDV疫苗的研发领域提供参考.
Abstract
The bovine viral diarrhea virus(BVDV)consists of 3 subspecies including BVDV-1,BVDV-2 and BVDV-3,and it is an important viral pathogen causing enormous losses to cattle industry.Vaccination is one of the main strategies for prophylaxis and contributes to the control and eradication of many viral diseases including BVDV.The structural proteins E2 and Erns of BVDV are the main antigenic proteins that induce production of neutralizing antibody and stimulate protective immune response,they are the also commonly used target proteins in BVDV vaccines research.In this review,we are focusing on the pathogenic structure of BVDV,the immune response of the host against the viral infection,and the recent advances of both classic vaccine and novel recombinant vaccine of BVDV,aiming at providing reference for the BVDV vaccine field.
关键词
BVDV/病原结构/免疫应答/免疫抑制/疫苗Key words
BVDV/Pathogen structure/Immune response/Immunosuppression/Vaccine引用本文复制引用
基金项目
黑龙江省农业科技创新跨越工程农业关键技术科技创新重点攻关项目(CX23GG07)
黑龙江省农科院畜牧兽医分院自拟课题(ZNKT-202212)
齐齐哈尔市科技计划创新激励项目(CNYGG-2023019)
出版年
2024
国家科技期刊平台
NSTL
万方数据