Study on the Preparation of Celquinome Sulfate Intramammary Infusion(Dry Cow)
In order to improve the stability of Cefquinoxime Sulfate intramammary infusion(dry cow),the preparation process of Cefquinoxime Sulfate intramammary infusion was improved.In this study,based on the screening of formulated excipients,through orthogonal test,soybean oil for injection as the solvent of the formulation,and the optimal proportioning amounts of 3%,3%and 0.2%were preferred to the stabilizer as glycerol monostearate,the suspending aid sodium carboxymethylcellulose as well as the antioxidant BHT using the indicators of sedimentation volume ratio,re-dispersion and flowability examination,and the preparation of cefquinome sulfate thixotropic fluid oil gel was prepared.Compared with similar products in the market,this improved preparation has better viscosity,more uniform particle size dispersion,good stability,and can effectively improve the preparation process of Cefquinoxime Sulfate intramammary infusion(dry cow).
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