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脑白质高信号消退的研究进展

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脑白质高信号(WMH)普遍存在于老年人群中,与卒中、认知、步态不稳和神经精神症状相关。WMH负荷通常随着年龄的增长而增加,但随着研究的不断深入,发现WMH是动态可变的,在发展过程中可能会部分消退,且可能伴随脑萎缩减缓和认知功能改善,但其确切发生机制、影响因素及临床意义目前尚不明确,且缺少有效逆转WMH的方法。作者综述了WMH消退的相关研究,为临床医师积极干预WMH相关影响因素,促进其在早期阶段逆转,改善患者脑健康提供参考。
Research progress on the cerebral white matter hyperintensities regression
White matter hyperintensities(WMH)is prevalent in the elderly population and is associated with stroke,cognition,gait instability,and neuropsychiatric symptoms.WMH burden usually increases with the growth of age.However,in recent years,there are researches found that WMH is actually dynamic variable.During the development,part of the WMH may regress,accompanied by the slowdown of brain atrophy and cognitive improvement.While,its mechanism,influencing factors and clinical significance remains unclear,and the effective treatment to reverse WMH is not clear.The article reviewed the current studies on the regression of WMH,aiming to provide reference for clinicians to actively perform intervention in the WMH related factors,promote their reversal in the early stage and improve the brain health of patients.

Cerebral small vessel diseasesWhite matterMagnetic resonance imagingReview

徐玉芸、方琪芬、龚向阳

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310014 杭州,浙江省人民医院(杭州医学院附属人民医院)放射科

杭州师范大学临床医学院

大脑小血管疾病 白质 磁共振成像 综述

浙江省基础公益研究计划

LGF22H090021

2024

中国脑血管病杂志
中国医师协会 首都医科大学宣武医院

中国脑血管病杂志

CSTPCD北大核心
影响因子:1.076
ISSN:1672-5921
年,卷(期):2024.21(3)
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