缺血性卒中后脑白质损伤机制研究进展
Research progress of mechanism study on white matter injury after ischemic stroke
黄馨蕾 1吕鹤群 1曾春利 1冯瑶婷 1彭拥军1
作者信息
- 1. 210029 南京中医药大学附属医院(江苏省中医院)针灸康复科
- 折叠
摘要
缺血性卒中具有高致残率、高致死率,且常伴有脑白质损伤(WMI).WMI患者常存在认知障碍、情绪障碍、感觉运动障碍、尿失禁等症状,严重影响日常生活.WMI可通过影像学技术早期发现,但目前缺少相应的干预手段及特异性治疗方法.研究缺血性卒中后WMI的病理机制有利于预防WMI发生,延缓其进展,有助于研发有效的治疗药物或特异性治疗手段.作者对缺血性卒中后WMI相关机制的研究进展进行了综述,以期为临床预防及治疗提供科学依据.
Abstract
Ischemic stroke has a high rate of disability and mortality and is often accompanied by white matter injury(WMI).WMI patients often have cognitive disorders,emotional disorders,sensorimotor disorders,urinary incontinence and other symptoms,which seriously affect daily life.WMI can be detected early through imaging techniques,but there is a lack of appropriate intervention and specific treatment.Studying the pathological mechanism of WMI after ischemic stroke is helpful to prevent the occurrence of WMI,delay its progression,and contribute to the development of effective drugs or specific treatments.This article reviewed the research progress of WMI mechanism after ischemic stroke in order to provide scientific basis for clinical prevention and treatment.
关键词
缺血性卒中/脑白质损伤/机制/综述Key words
Ischemic stroke/White matter injury/Mechanism/Review引用本文复制引用
基金项目
国家自然科学基金(82374565)
国家自然科学基金(82174484)
出版年
2024
国家科技期刊平台
NSTL
万方数据