环腺苷酸激活交换蛋白1/RAS相关蛋白1信号通路在脑缺血-再灌注损伤发病机制中的研究进展
Research progress of cyclic AMP-activated exchange protein 1/RAS-related protein 1 signal pathway in the pathogenesis of cerebral ischemia-reperfusion injury
吕雪 1孙毅红 1华志鹏 1贾建新1
作者信息
- 1. 014010 内蒙古科技大学包头医学院研究生院
- 折叠
摘要
脑缺血-再灌注损伤(CIRI)是缺血性卒中患者恢复患侧脑组织血流时引发的严重并发症.CIRI患者常伴有神经功能减退、认知障碍、情绪障碍等,对日常生活产生严重影响.目前CIRI易被早期诊断,但相关特异性治疗方法相对较少.作者对环腺苷酸激活交换蛋白1/RAS相关蛋白1(Epac1/Rap1)信号通路与CIRI的相关性研究进行综述,以期为CIRI患者的临床治疗提供新思路.
Abstract
Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.
关键词
脑缺血再灌注损伤/Epac1/Rap1信号通路/发病机制/综述Key words
Cerebral ischemia-reperfusion injury/Epac1/Rap1 signaling pathway/Pathogenesis/Review引用本文复制引用
基金项目
国家自然科学基金(81860215)
内蒙古自治区自然科学基金(2021MS08010)
出版年
2024
国家科技期刊平台
NSTL
万方数据