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放射治疗后颈动脉狭窄的分子机制研究进展

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近年来,放射治疗在头颈部肿瘤治疗中的广泛应用,显著提高了患者的生存期.然而,放射治疗引发的颈动脉狭窄问题日益受到关注.放射治疗后颈动脉狭窄具有多发、长节段及病变不稳定等特点,传统治疗手段难以应对.作者系统性总结了放射治疗引发颈动脉狭窄的病理特征及机制,探讨了内皮细胞、平滑肌细胞和滋养血管损伤在其中的作用,并对其未来研究方向及防治策略进行了展望.
Advances in molecular mechanisms of carotid artery stenosis after radiotherapy
In recent years,radiation therapy has become a cornerstone in the treatment of head and neck tumors,significantly improving patient survival rates.However,the issue of radiation-induced carotid artery stenosis has garnered increasing attention.Characterized by multiple,long-segment,and unstable lesions,radiation-induced carotid stenosis presents unique challenges that traditional therapeutic approaches struggle to address.This review systematically summarized the pathological features and underlying mechanisms of radiation-induced carotid stenosis,with a focus on the roles of endothelial cells,smooth muscle cells,and vasa vasorum damage.Future research directions and preventive strategies are also discussed.

Carotid artery stenosisRadiotherapyMolecular mechanismReview

张潇、崔晟岩、徐然、李家耀、焦力群、王韬

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100053 北京,首都医科大学宣武医院神经外科

100053 北京,首都医科大学宣武医院介入放射科

颈动脉狭窄 放射治疗 分子机制 综述

国家自然科学基金青年科学基金项目

82301468

2024

中国脑血管病杂志
中国医师协会 首都医科大学宣武医院

中国脑血管病杂志

CSTPCD北大核心
影响因子:1.076
ISSN:1672-5921
年,卷(期):2024.21(9)