放射治疗后颈动脉狭窄的分子机制研究进展
Advances in molecular mechanisms of carotid artery stenosis after radiotherapy
张潇 1崔晟岩 1徐然 1李家耀 1焦力群 2王韬1
作者信息
- 1. 100053 北京,首都医科大学宣武医院神经外科
- 2. 100053 北京,首都医科大学宣武医院介入放射科
- 折叠
摘要
近年来,放射治疗在头颈部肿瘤治疗中的广泛应用,显著提高了患者的生存期.然而,放射治疗引发的颈动脉狭窄问题日益受到关注.放射治疗后颈动脉狭窄具有多发、长节段及病变不稳定等特点,传统治疗手段难以应对.作者系统性总结了放射治疗引发颈动脉狭窄的病理特征及机制,探讨了内皮细胞、平滑肌细胞和滋养血管损伤在其中的作用,并对其未来研究方向及防治策略进行了展望.
Abstract
In recent years,radiation therapy has become a cornerstone in the treatment of head and neck tumors,significantly improving patient survival rates.However,the issue of radiation-induced carotid artery stenosis has garnered increasing attention.Characterized by multiple,long-segment,and unstable lesions,radiation-induced carotid stenosis presents unique challenges that traditional therapeutic approaches struggle to address.This review systematically summarized the pathological features and underlying mechanisms of radiation-induced carotid stenosis,with a focus on the roles of endothelial cells,smooth muscle cells,and vasa vasorum damage.Future research directions and preventive strategies are also discussed.
关键词
颈动脉狭窄/放射治疗/分子机制/综述Key words
Carotid artery stenosis/Radiotherapy/Molecular mechanism/Review引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(82301468)
出版年
2024
国家科技期刊平台
NSTL
万方数据