Advances of the thrombospondin type 1 domain containing protein 1 in intracranial aneurysms formation and rupture
Intracranial aneurysm(IA)is the predominant cause of subarachnoid haemorrhage and is characterised by high mortality and disability.Small holes and enlarged gaps are detected in the junctions of endothelial cells on the surface of the IA endothelial lumen under electron microscopy.Focal adhesions(FA)are complex macromolecular complex structures that connect extracellularly and serve to maintain cerebrovascular integrity.Thrombospondin type 1 domain containing protein 1(THSD1)and talin interact to tether endothelial cells to the underlying basement membrane,assembling to form FA and promoting its maturation to maintain endothelial integrity.THSD1 can regulate the number and function through the endocytosis pathway and small interfering ribonucleic acids.When THSD1 mutates,its translated protein THSD1 functions abnormally,making it prone to IA.This review summarized the location and function of the THSD1 gene,the pathogenic mechanism of IA,the relationship between THSD1 and IA formation,and the regulation of THSD1 function,with the aim of providing new ideas and treatment targets for the treatment of IA.
万方数据
维普
