Effects of GSPs and VE on Growth Performance, Serum Redox Status and Hepatic Oxidative Damage in Piglets Under Oxidative Stress
[Objective] The aim of this study was to investigate the effects of dietary grape seed procyanidins (GSPs) or vitamin E (VE) on growth performance,serum redox status and liver oxidative damage in piglets under oxidative stress.[Method]Twenty-four weaned piglets (L×Y) at 28 d of age were allotted into 4 groups with 6 replicates per group and 1 piglet per replicate.Piglets in NC group or Diquat group were fed with basal diet,and those in GSPs+Diquat group or VE+Diquat group were fed with basal diets supplemented with 100 mg·kg1 GSPs or 50 mg·kg1 VE,respectively.On d 10,all the piglets in Diquat,GSPs+Diquat and VE+Diquat groups were injected intraperitoneally with Diquat (10 mg-kg-1),and those in NC group were injected with the same amount of sterile saline.The experiment lasted for 17 days.[Result] The results showed that Diquat injection caused the reduction of growth performance,anti-oxidant capacities of serum and liver,activities of hepatic ALT and AST(P＜0.05),while increased serum ALT and AST activities (P＜0.05).100 mg·kg-1 GSPs or 50 mg·kg-1 VE supplementation improved serum GSH-px activity,capacity of anti-superoxide anion as well as hepatic ALT and AST activities (P＜0.05),and decreased ALT and AST activities and MDA content in serum (P＜0.05).Furthermore,GSPs also significantly enhanced serum SOD activity and anti-hydroxyl radical capacity,improved hepatic T-AOC and capacities of anti-hydroxyl radical,and reduced MDA content in liver (P＜ 0.05).[Conclusion] Dietary supplementation of 100 mg·kg1 of GSPs or 50 mg·kg-1 of VE can suppress the oxidative stress caused by Diquat injection in piglets,and GSPs exert a better antioxidant capacity in serum and liver.
国家科技期刊平台
NSTL
万方数据
维普
