Effects of Adding Curcumin to Perinatal Diets on Production Performance,Blood Indexes and Gene Expression of Inflammatory Factors in Goats
[Background]The reproductive capacity of goat has a direct impact on the mutton sheep industry,and the perinatal period is a special physiological period in the goat breeding process.During this stage,the feed intake and energy intake decreases,and the nutritional needs of the offspring increase sharply.Goats are prone to enter a state of negative energy balance,which can induce a series of adverse reactions,such as metabolic diseases,inflammatory reactions,immune suppression,and even miscarriage.[Objective]This study aimed to investigate the alleviation role of curcumin in the perinatal diet on negative energy balance state of goats,by evaluating goat production performance,blood indicators and inflammatory factor gene expression,to improve the health of perinatal goats.[Method]Eighteen Subai goats with 122 days of gestation(i.e.28 days before delivery)were divided into Con group(no supplement)and Cur group(supplemented with curcumin 800 mg·kg-1 DMI).Blood sample was collected on 21 days(d-21)before delivery and 0(d0)and 21 days(d21)after delivery.Goat production performance,blood indicators and inflammatory factor gene expression were measured.[Result]Cur treatment did not affect goat feed intake,birth weight or daily gain of lambs.The goat feed intake of both groups before and after delivery tended to decrease and then increase,with the lowest feed intake on the day of delivery(P=0.097).Cur treatment tended to increase serum Glu concentration(P=0.075).Cur treatment significantly reduced serum NEFA content on d0 and d21(P＜0.05),but did not affect serum low-density lipoprotein,high-density lipoprotein,total cholesterol,or triglyceride content(P＞0.05).Cur treatment tended to increase serum total T-AOC level on d21(P=0.073),and significantly reduced serum MDA content on d0,but did not affect serum SOD or GSH-Px level(P＞0.05).Cur treatment did not affect serum IgA,IgG or IgM content(P＞0.05).Cur treatment significantly increased the expression of Nrf2 in whole blood on d21(P＜0.05)and decreased the expression of TNFα on d0(P＜0.05),but did not affect the gene expression of IL-1,IL-6 and IFNγ(P＞0.05).[Conclusion]Adding curcumin to peripartum diets could reduce serum NEFA level,enhance antioxidant properties,and reduce inflammatory responses to a certain extent in goats.
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